Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jul 1;146(1):277-81.
doi: 10.1084/jem.146.1.277.

Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi

L H Miller, J D Haynes, F M McAuliffe, T Shiroishi, J R Durocher, M H McGinniss

Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi

L H Miller et al. J Exp Med. .

Abstract

Human erythrocytes lacking various blood group determinants were susceptible to invasion by Plasmodium falciparum including Duffy-negative erythrocytes that are refractory to invasion by Plasmodium knowlesi. Erythrocytes treated with trypsin or neuraminidase had reduced susceptibility of P. falciparum and normal susceptibility to P. knowlesi. Chymotrypsin treatment (0.1 mg/ml) blocked invasion only by P. knowlesi. The differential effect of enzymatic cleavage of determinats from the erythrocyte surface on invasion by these parasites suggests that P. falciparum and P. knowlesi interact with different determinants on the erythrocyte surface.

PubMed Disclaimer

References

    1. J Exp Med. 1953 Jun;97(6):773-82 - PubMed
    1. Nature. 1976 Oct 28;263(5580):767-9 - PubMed
    1. J Biol Chem. 1976 Oct 10;251(19):6108-16 - PubMed
    1. Biochemistry. 1971 Jun 22;10(13):2617-24 - PubMed
    1. J Exp Med. 1973 Dec 1;138(6):1597-601 - PubMed