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Review
. 2020 Sep;30(5):672-678.
doi: 10.1097/MOU.0000000000000797.

Where to next prostate-specific membrane antigen PET imaging frontiers?

Maarten L Donswijk  1 , Joshua J Morigi  2 , Adrienne Little  2 , Wouter V Vogel  1   3 , Pim J van Leeuwen  4
Affiliations
Review

Where to next prostate-specific membrane antigen PET imaging frontiers?

Maarten L Donswijk et al. Curr Opin Urol. 2020 Sep.

Abstract

Purpose of review: Technical improvements in imaging equipment and availability of radiotracers, such as PSMA-ligands have increased the synergy between Urology and Nuclear Medicine. Meanwhile artificial intelligence is introduced in Nuclear Imaging. This review will give an overview of recent technical and clinical developments and an outlook on application of these in the near future.

Recent findings: Digital PET/CT has shown gradual improvement in lesion detection and demarcation over conventional PET/CT, but total-body PET/CT holds promise for a magnitude of improvement in scan duration and quality, quantification, and dose optimization. PET-guided decision-making with the application of PSMA-ligands has been shown useful in demonstrating and biopting primary prostate cancer (PCa) lesions, guiding radiotherapy, guiding surgical resection of recurrent PCa, and assessing therapy response in PCa. Artificial intelligence made its way into Nuclear Imaging just recently, but encouraging progress promises clinical application with unprecedented possibilities.

Summary: Evidence is growing on clinical usefulness of PET-guided decision-making with the still relatively new PSMA ligands as a prime example. Rapid evolution of PET instrumentation and clinical introduction of artificial intelligence will be the gamechangers of nuclear imaging in the near future, though its powers should still be mastered and incorporated in clinical practice.

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References

    1. Mottet, N, Cornford, P, van den Bergh RCN et al. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer 2020 published guidelines.
    1. Alberts I, Prenosil G, Sachpekidis C, et al. Digital versus analogue PET in [(68)Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison. Eur J Nucl Med Mol Imaging 2020; 47:614–623.
    1. van Sluis J, Boellaard R, Somasundaram A, et al. Image quality and semiquantitative measurements on the biograph vision PET/CT system: initial experiences and comparison with the biograph mCT. J Nucl Med 2020; 61:129–135.
    1. Koopman D, van Dalen JA, Stevens H, et al. Performance of digital PET compared to high-resolution conventional PET in patients with cancer. J Nucl Med 2020; doi:10.2967/jnumed.119.238105. - DOI
    1. Cherry SR, Jones T, Karp JS, et al. Total-body PET: maximizing sensitivity to create new opportunities for clinical research and patient care. J Nucl Med 2018; 59:3–12.

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