Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul 23;16(7):e1008625.
doi: 10.1371/journal.ppat.1008625. eCollection 2020 Jul.

Whoop! There it is: The surprising resurgence of pertussis

Audra R Fullen  1 , Kacy S Yount  1 , Purnima Dubey  1   2 , Rajendar Deora  1   3
Affiliations

Whoop! There it is: The surprising resurgence of pertussis

Audra R Fullen et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Reasons for and research directions to control pertussis resurgence.
Resurgence of aPV is attributed to (A) genotypic and antigenic variation and the differential production of virulence factors between currently circulating strains (CBp) and the reference strains; (B) increased aggregation, biofilm formation, adhesion, and colonization phenotypes of CBp strains; (C) inability to reduce nasopharyngeal colonization; (D) subsequent transmission; and (E) suboptimal immune response induced by alum, an adjuvant in aPV which drives Th2 and antibody responses instead of the Th1/17 responses required for protection of the respiratory tract. (F) Multiple approaches are suggested with the goal of developing novel and more effective next-generation aPV. aPV, acellular pertussis vaccine; Bp, Bordetella pertussis; cBp, circulating Bp.
See this image and copyright information in PMC

References

    1. Mills KH, Ross PJ, Allen AC, Wilk MM. Do we need a new vaccine to control the re-emergence of pertussis? Trends Microbiol. 2014;22(2):49–52. Epub 2014/02/04. S0966-842X(13)00232-1 [pii] 10.1016/j.tim.2013.11.007 . - DOI - PubMed
    1. Burdin N, Handy LK, Plotkin SA. What Is Wrong with Pertussis Vaccine Immunity? The Problem of Waning Effectiveness of Pertussis Vaccines. Cold Spring Harb Perspect Biol. 2017;9(12). Epub 2017/03/16. 10.1101/cshperspect.a029454 . - DOI - PMC - PubMed
    1. Ring N, Abrahams JS, Bagby S, Preston A, MacArthur I. How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis. Adv Exp Med Biol. 2019. Epub 2019/07/20. 10.1007/5584_2019_401 . - DOI - PubMed
    1. Weigand MR, Peng Y, Batra D, Burroughs M, Davis JK, Knipe K, et al. Conserved Patterns of Symmetric Inversion in the Genome Evolution of Bordetella Respiratory Pathogens. mSystems. 2019;4(6). Epub 2019/11/21. 10.1128/mSystems.00702-19 - DOI - PMC - PubMed
    1. Carbonetti NH. Bordetella pertussis: new concepts in pathogenesis and treatment. Curr Opin Infect Dis. 2016;29(3):287–94. Epub 2016/02/26. 10.1097/QCO.0000000000000264 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances