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. 2020 Jul 23;16(7):e1008625.
doi: 10.1371/journal.ppat.1008625. eCollection 2020 Jul.

Whoop! There it is: The surprising resurgence of pertussis

Audra R Fullen  1 , Kacy S Yount  1 , Purnima Dubey  1   2 , Rajendar Deora  1   3
Affiliations

Whoop! There it is: The surprising resurgence of pertussis

Audra R Fullen et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Reasons for and research directions to control pertussis resurgence.
Resurgence of aPV is attributed to (A) genotypic and antigenic variation and the differential production of virulence factors between currently circulating strains (CBp) and the reference strains; (B) increased aggregation, biofilm formation, adhesion, and colonization phenotypes of CBp strains; (C) inability to reduce nasopharyngeal colonization; (D) subsequent transmission; and (E) suboptimal immune response induced by alum, an adjuvant in aPV which drives Th2 and antibody responses instead of the Th1/17 responses required for protection of the respiratory tract. (F) Multiple approaches are suggested with the goal of developing novel and more effective next-generation aPV. aPV, acellular pertussis vaccine; Bp, Bordetella pertussis; cBp, circulating Bp.
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