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Observational Study
. 2020 Dec 1;116(14):2185-2196.
doi: 10.1093/cvr/cvaa209.

The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study

Kenneth Mangion  1   2 , Andrew Morrow  1   2 , Catherine Bagot  3 , Hannah Bayes  4 , Kevin G Blyth  5   6 , Colin Church  5 , David Corcoran  1   2 , Christian Delles  1 , Lynsey Gillespie  7 , Douglas Grieve  8 , Antonia Ho  9 , Sharon Kean  10 , Ninian N Lang  1   2 , Vera Lennie  11 , David J Lowe  12 , Peter Kellman  13 , Peter W Macfarlane  14 , Alex McConnachie  9 , Giles Roditi  1   15 , Robert Sykes  1   16 , Rhian M Touyz  1   2 , Naveed Sattar  1 , Ryan Wereski  2   11   17 , Sylvia Wright  1   8 , Colin Berry  1   2
Affiliations
Observational Study

The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study

Kenneth Mangion et al. Cardiovasc Res. .

Abstract

Background: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear.

Methods: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation.

Conclusion: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.

Clinical trial registration: ClinicalTrials.gov identifier NCT04403607.

Keywords: Biomarkers; Imaging; Myocardial infarction; Myocardial inflammation; Myocardial injury; SARS-CoV-2.

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Figures

Figure 1
Figure 1
Cardiovascular pathophysiology of COVID-19. With permission of T. Guzik et al. Cardiovascular Research 2020.
Figure 2
Figure 2
Schematic study design: flow diagram. The time periods are from hospital discharge. Abbreviations: CTCA, omputed tomography coronary angiography; ECG, electrocardiogram; Q, questionnaires; MRI, stress perfusion cardiac magnetic resonance imaging.
Figure 3
Figure 3
Primary outcome evaluation.
See this image and copyright information in PMC

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