Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jul 22;107(2):205-207.
doi: 10.1016/j.neuron.2020.06.024.

A Novel Neurovascular Liaison Governing the Blood-Brain Barrier

Makoto Ishii  1 , Costantino Iadecola  2
Affiliations
Comment

A Novel Neurovascular Liaison Governing the Blood-Brain Barrier

Makoto Ishii et al. Neuron. .

Abstract

How circulating signals enter the median eminence to trigger homeostatic hypothalamic responses is not well understood. Jiang et al. describe a neural mechanism that increases endothelial fenestrations and enhances the hypothalamic response to the circulating hormone leptin, suggesting a novel way to regulate brain entry through vascular wall remodeling.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests C.I. serves on the Scientific Advisory Board of Broadview Ventures.

Figures

Figure 1.
Figure 1.. Regulation of Permeability of Median Eminence Capillary Loops by MCH Neurons
Melanin concentrating hormone (MCH) neurons projecting to the capillary loops and tanycytes in the median eminence release VEGF, resulting in an increase in the number of fenestrations in endothelial cells and promote the effect of circulating hormones on the hypothalamus.
See this image and copyright information in PMC

Comment on

  • MCH Neurons Regulate Permeability of the Median Eminence Barrier.
    Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC. Jiang H, et al. Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13. Neuron. 2020. PMID: 32407670 Free PMC article.

References

    1. Arrigoni E, Chee MJS, and Fuller PM (2019). To eat or to sleep: That is a lateral hypothalamic question. Neuropharmacology 154, 34–49. - PubMed
    1. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, FalluelMorel A, Anouar Y, Dehouck B, et al. (2014). Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab. 19, 293–301. - PMC - PubMed
    1. Ishii M, and Iadecola C (2015). Metabolic and Non-Cognitive Manifestations of Alzheimer’s Disease: The Hypothalamus as Both Culprit and Target of Pathology. Cell Metab. 22, 761–776. - PMC - PubMed
    1. Ishii M, Hiller AJ, Pham L, McGuire MJ, Iadecola C, and Wang G (2019). Amyloid-Beta Modulates Low-Threshold Activated VoltageGated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction. J. Neurosci 39, 8816–8825. - PMC - PubMed
    1. Jiang H, Gallet S, Klemm P, Scholl P, FolzDonahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, et al. (2020). MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. S0896–6273(20)30312–3. 10.1016/j.neuron.2020.04.020. - DOI - PMC - PubMed

LinkOut - more resources