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Meta-Analysis
. 2020 Jul 17;99(29):e21374.
doi: 10.1097/MD.0000000000021374.

Gray matter alterations in restless legs syndrome: A coordinate-based meta-analysis

LiQin Sheng  1 , PanWen Zhao  2 , HaiRong Ma  1 , Liang Qi  3 , ZhongQuan Yi  2 , YuanYuan Shi  2 , JianGuo Zhong  4 , HaiCun Shi  4 , ZhenYu Dai  5 , PingLei Pan  2   4
Affiliations
Meta-Analysis

Gray matter alterations in restless legs syndrome: A coordinate-based meta-analysis

LiQin Sheng et al. Medicine (Baltimore). .

Erratum in

  • Study Protocol Titles: Erratum.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2020 Aug 14;99(33):e21984. doi: 10.1097/MD.0000000000021984. Medicine (Baltimore). 2020. PMID: 32872085 Free PMC article. No abstract available.

Abstract

Background: Voxel-based morphometry (VBM) is an objective structural magnetic resonance imaging (MRI) technique which allows researchers to investigate group-level differences in regional gray matter (GM) volume or density over the whole brain. In the last decade, VBM studies in restless leg syndrome (RLS) have exhibited inconsistent and conflicting findings.

Methods: Studies will be identified through a computerized literature search of the following databases: PubMed, Web of Science, and Embase until October 1, 2018 and updated on March 1, 2020. This protocol will be performed in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P). In addition, we will follow the recent guidelines and recommendations for coordinate-based meta-analysis (CBMA). This CBMA will be performed with the seed-based d mapping with permutation of subject images (SDM-PSI) software.

Results: This CBMA will offer the latest evidence of GM alterations in RLS.

Conclusions: To our knowledge, this will be the first CBMA that pooled VBM findings in RLS. This quantitative evidence of GM alterations will characterize brain morphometry of RLS.

Prospero registration number: CRD42018117014.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Study selection process in accordance with the PRISMA flowchart. PRISMA = Preferred Reporting Items of Systematic Review and Meta-Analysis.
See this image and copyright information in PMC

References

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