Current advances of long non-coding RNAs mediated by wnt signaling in glioma
- PMID: 32703485
- DOI: 10.1016/j.prp.2020.153008
Current advances of long non-coding RNAs mediated by wnt signaling in glioma
Abstract
Glioma is the most common and aggressive brain tumor in the central nervous system (CNS), in which Wnt signaling pathway has been verified to play a pivotal role in regulating the initiation and progression. Currently, numerous studies have indicated that long non-coding RNAs (lncRNAs) have critical functions across biological processes including cell proliferation, colony formation, migration, invasion and apoptosis via Wnt signaling pathway in glioma. This review depicts canonical and non-canonical Wnt/β-catenin signaling pathway properties and relative processing mechanisms in gliomas, and summarizes the function and regulation of lncRNAs mediated by Wnt signaling pathway in the development and progression of glioma. Ultimately, we hope to seek out promising biomarkers and reliable therapeutic targets for glioma.
Keywords: Biomarkers; Glioma; LncRNAs; Therapeutic targets; Wnt signaling pathway.
Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest The authors declare no conflict of interest.
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