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Review
. 2020 Apr;24(Suppl 3):S107-S111.
doi: 10.5005/jp-journals-10071-23391.

Solute and Volume Dosing during Kidney Replacement Therapy in Critically Ill Patients with Acute Kidney Injury

Raghavan Murugan  1
Affiliations
Review

Solute and Volume Dosing during Kidney Replacement Therapy in Critically Ill Patients with Acute Kidney Injury

Raghavan Murugan. Indian J Crit Care Med. 2020 Apr.

Abstract

Among critically ill patients with severe acute kidney injury either continuous kidney replacement therapy (CKRT) or intermittent hemodialysis (IHD) can be performed to provide optimal solute and volume control. The modality of KRT should be chosen based on the needs of the patient, hemodynamic status, clinician expertise, and resource available under a particular setting and consideration of costs. Evidence from high-quality randomized trials suggests that an effluent flow rate of 25 mL/kg/hour per day using CKRT and Kt/V of 1.3 per session of IHD provide optimal solute control. For volume dosing, the net ultrafiltration (UFNET) rate should be prescribed based on patient body weight in milliliters per kilogram per hour, with close monitoring of patient hemodynamics and fluid balance. Emerging evidence from observational studies suggests a "J"-shaped association between UFNET rate and outcomes with both faster and slower UFNET rates being associated with increased mortality compared with moderate UFNET rates. Thus, randomized trials are required to determine optimal UFNET rates in critically ill patients.

How to cite this article: Murugan R. Solute and Volume Dosing during Kidney Replacement Therapy in Critically Ill Patients with Acute Kidney Injury. Indian J Crit Care Med 2020;24(Suppl 3):S107-S111.

Keywords: Dosing; Kidney replacement therapy; Solute control; Volume control.

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Conflict of interest statement

Source of support: National Institute of Diabetes and Digestive and Kidney Disease grant (5R01DK106256) Conflict of interest: Dr Murugan reported receiving grants and personal fees from La Jolla Inc; grants from Bioporto, Inc, and the National Institute of Diabetes and Digestive and Kidney Diseases; and personal fees from Beckman Coulter and AM Pharma, Inc, outside the submitted work

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