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. 2020 Sep 10;383(11):1071-1077.
doi: 10.1056/NEJMsr2022263. Epub 2020 Jul 22.

Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States - The NIH RADx Initiative

Bruce J Tromberg  1 , Tara A Schwetz  1 , Eliseo J Pérez-Stable  1 , Richard J Hodes  1 , Richard P Woychik  1 , Rick A Bright  1 , Rachael L Fleurence  1 , Francis S Collins  1
Affiliations

Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States - The NIH RADx Initiative

Bruce J Tromberg et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. RADx-tech Innovation Funnel to Evaluate Testing Technologies for Covid-19.
Applications to the Rapid Acceleration of Diagnostics (RADx)–tech program for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (Covid-19), move rapidly through an “innovation funnel” from phase 0 to phase 1 to phase 2, with increasing selection pressure at each gate. The RADx–Advanced Technologies Platforms (RADx-ATP) program identifies projects that are more advanced and that can be moved immediately to phase 1 or even phase 2.
Figure 2
Figure 2. Number of RADx-tech Proposals, According to Organization Type.
The majority of applications to the RADx-tech and the RADx-ATP programs have come from small businesses, academic laboratories, and early-stage start-up companies.
Figure 3
Figure 3. Sample Types in RADx-tech and RADx-ATP Proposals.
Applications to RADx-tech and RADx-ATP include multiple alternative sampling strategies for viral testing, not just traditional nasal swabs.
See this image and copyright information in PMC

References

    1. Center for Systems Science and Engineering at Johns Hopkins University. COVID-19 dashboard. 2020. (https://coronavirus.jhu.edu/map.html).
    1. Webb Hooper M, Nápoles AM, Pérez-Stable EJ. COVID-19 and racial/ethnic disparities. JAMA 2020. May 11 (Epub ahead of print). - PMC - PubMed
    1. Stokes EK, Zambrano LD, Anderson KN, et al. Coronavirus disease 2019 case surveillance — United States, January 22–May 30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:759-765. - PMC - PubMed
    1. Collins FS, Stoffels P. Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): an unprecedented partnership for unprecedented times. JAMA 2020. May 18 (Epub ahead of print). - PubMed
    1. The COVID Tracking Project. US historical data 2020. (https://covidtracking.com/data/us-daily).

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