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Review
. 2020 Jul 22;25(15):3322.
doi: 10.3390/molecules25153322.

Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

Olga Pechanova  1 , Ezgi Dayar  1 , Martina Cebova  1
Affiliations
Review

Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

Olga Pechanova et al. Molecules. .

Abstract

Numerous studies document an increased production of reactive oxygen species (ROS) with a subsequent decrease in nitric oxide (NO) bioavailability in different cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. Many natural polyphenols have been demonstrated to decrease ROS generation and/or to induce the endogenous antioxidant enzymatic defense system. Moreover, different polyphenolic compounds have the ability to increase the activity/expression of endothelial nitric oxide synthase (eNOS) with a subsequent enhancement of NO generation. However, as a result of low absorption and bioavailability of natural polyphenols, the beneficial effects of these substances are very limited. Recent progress in delivering polyphenols to the targeted tissues revealed new possibilities for the use of polymeric nanoparticles in increasing the efficiency and reducing the degradability of natural polyphenols. This review focuses on the effects of different natural polyphenolic substances, especially resveratrol, quercetin, curcumin, and cherry extracts, and their ability to bind to polymeric nanoparticles, and summarizes the effects of polyphenol-loaded nanoparticles, mainly in the cardiovascular system.

Keywords: ROS; atherosclerosis; cherry extracts; curcumin; heart failure; hypertension; nitric oxide; polymeric nanoparticles; quercetin; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cardiovascular diseases, including hypertension, atherosclerosis, and heart failure are accompanied by increased production of reactive oxygen species (ROS), also via enhanced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, with subsequent decreased nitric oxide (NO) generation, leading to endothelial dysfunction. Many natural polyphenols like resveratrol, quercetin, or curcumin are able to fight endothelial dysfunction by their ability to decrease ROS generation, induce the endogenous antioxidant enzymatic defense system, and increase activity/expression of endothelial NO synthase (eNOS).
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