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Review
. 2020 Jul 17;8(7):223.
doi: 10.3390/biomedicines8070223.

Key Milestones Contributing to the Understanding of the Mechanisms Underlying Fibromyalgia

Geoffrey Littlejohn  1   2 , Emma Guymer  1   2
Affiliations
Review

Key Milestones Contributing to the Understanding of the Mechanisms Underlying Fibromyalgia

Geoffrey Littlejohn et al. Biomedicines. .

Abstract

The promulgation of the American College of Rheumatology (ACR) 1990 criteria for fibromyalgia (FM) classification has significantly contributed to an era of increased research into mechanisms that underlie the disorder. The previous emphasis on putative peripheral nociceptive mechanisms has advanced to identifying of changes in central neural networks that modulate pain and other sensory processes. The influences of psychosocial factors on the dynamic and complex neurobiological mechanisms involved in the fibromyalgia clinical phenotype are now better defined. This review highlights key milestones that have directed knowledge concerning the fundamental mechanisms contributing to fibromyalgia.

Keywords: 1990 ACR criteria; central sensitization; fibromyalgia; mechanisms.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The 1990 ACR criteria accelerated and broadened the curve of knowledge of mechanisms contributing to fibromyalgia in many overlapping domains.
See this image and copyright information in PMC

References

    1. Wolfe F., Smythe H.A., Yunus M.B., Bennett R.M., Bombardier C., Goldenberg D.L., Tugwell P., Campbell S.M., Abeles M., Clark P., et al. The American college of rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 1990;33:160–172. doi: 10.1002/art.1780330203. - DOI - PubMed
    1. Hauser W., Ablin J., Fitzcharles M.A., Littlejohn G., Luciano J.V., Usui C., Walitt B. Fibromyalgia. Nat. Rev. Dis. Primers. 2015;1:15022. doi: 10.1038/nrdp.2015.22. - DOI - PubMed
    1. Inanici F., Yunus M.B. History of fibromyalgia: Past to present. Curr. Pain Headache Rep. 2004;8:369–378. doi: 10.1007/s11916-996-0010-6. - DOI - PubMed
    1. Wallace D. History of fibromyalgia. In: Clauw D., Wallace D., editors. Fibromyalgia. The Essential Clinicians Guide. Oxford University Press; Oxford, UK: 2009. pp. 1–5.
    1. Smythe H.A., Moldofsky H. Two contributions to understanding of the “fibrositis” syndrome. Bull. Rheum. Dis. 1977;28:928–931. - PubMed

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