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Comment
. 2020 Sep;26(9):799-800.
doi: 10.1016/j.molmed.2020.07.001. Epub 2020 Jul 22.

Dysfunctional T Cell Mitochondria Lead to Premature Aging

Guy Lenaers  1 , Dominique Bonneau  2 , Yves Delneste  3 , Nicolas Papon  4
Affiliations
Comment

Dysfunctional T Cell Mitochondria Lead to Premature Aging

Guy Lenaers et al. Trends Mol Med. 2020 Sep.

Abstract

Desdín-Micó et al. have shown that Tfam specific knockout in mouse T cells disrupts mitochondrial genome integrity and induces a burst of inflammatory cytokines and tumor necrosis factor (TNF)-α production, resulting in increased senescence, neuromuscular and vascular dysfunction, and molecular features that recapitulate premature aging. Interestingly, treatment with nicotinamide riboside (NR) alleviates this phenotype by reducing senescence and systemic inflammation.

Keywords: T cells; cytokine; mitochondria; premature aging; senescence.

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  • T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.
    Desdín-Micó G, Soto-Heredero G, Aranda JF, Oller J, Carrasco E, Gabandé-Rodríguez E, Blanco EM, Alfranca A, Cussó L, Desco M, Ibañez B, Gortazar AR, Fernández-Marcos P, Navarro MN, Hernaez B, Alcamí A, Baixauli F, Mittelbrunn M. Desdín-Micó G, et al. Science. 2020 Jun 19;368(6497):1371-1376. doi: 10.1126/science.aax0860. Epub 2020 May 21. Science. 2020. PMID: 32439659 Free PMC article.

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