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Comment
. 2020 Oct;16(10):543-544.
doi: 10.1038/s41584-020-0472-7.

The (Orf)ull truth about IRF5 and type I interferons in SLE

Keith B Elkon  1 , Tracy A Briggs  2   3
Affiliations
Comment

The (Orf)ull truth about IRF5 and type I interferons in SLE

Keith B Elkon et al. Nat Rev Rheumatol. 2020 Oct.
No abstract available

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Comment on

  • TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
    Heinz LX, Lee J, Kapoor U, Kartnig F, Sedlyarov V, Papakostas K, César-Razquin A, Essletzbichler P, Goldmann U, Stefanovic A, Bigenzahn JW, Scorzoni S, Pizzagalli MD, Bensimon A, Müller AC, King FJ, Li J, Girardi E, Mbow ML, Whitehurst CE, Rebsamen M, Superti-Furga G. Heinz LX, et al. Nature. 2020 May;581(7808):316-322. doi: 10.1038/s41586-020-2282-0. Epub 2020 May 13. Nature. 2020. PMID: 32433612 Free PMC article.

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    1. Bentham, J. et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. 47, 1457–1464 (2015). - DOI
    1. Heinz, L. X. et al. TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. Nature 581, 316–322 (2020). - DOI
    1. Fitzgerald, K. A. & Kagan, J. C. Toll-like receptors and the control of immunity. Cell 180, 1044–1066 (2020). - DOI
    1. Elkon, K. B. Review: cell death, nucleic acids, and immunity: inflammation beyond the grave. Arthritis Rheumatol. 70, 805–816 (2018). - DOI

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