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Review
. 2020 Oct;55(10):2556-2564.
doi: 10.1002/ppul.24981. Epub 2020 Aug 4.

Insight into the pediatric and adult dichotomy of COVID-19: Age-related differences in the immune response to SARS-CoV-2 infection

Allison Fialkowski  1 , Yael Gernez  2 , Puneeta Arya  1   3 , Katja G Weinacht  4 , T Bernard Kinane  1   5 , Lael M Yonker  1   5
Affiliations
Review

Insight into the pediatric and adult dichotomy of COVID-19: Age-related differences in the immune response to SARS-CoV-2 infection

Allison Fialkowski et al. Pediatr Pulmonol. 2020 Oct.

Abstract

The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.

Keywords: SARS-CoV-2 infection; age-related immune response; childhood COVID-19; pediatric COVID-19.

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References

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