Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul 1;21(7):1891-1897.
doi: 10.31557/APJCP.2020.21.7.1891.

Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Thanarpan Peerawong  1 , Yuthasak Suphasynth  2 , Chanon Kongkamol  3 , Paytai Rordlamool  1 , Jidapa Bridhikitti  1 , Rungarun Jiratrachu  1 , Duangjai Sangtawan  1 , Thiti Atjimakul  2 , Saibua Chicharoen  2
Affiliations

Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Thanarpan Peerawong et al. Asian Pac J Cancer Prev. .

Abstract

Objective: Cervical cancer is the second most common cancer in Thailand. For cervical cancer, there is no cancer specific quality of life questionnaire. This study aims to develop and validate Thai FACT-CX.

Methods: The cross-sectional study included all women aged ≥18 years with stage IB2-IIIB who planned to undergo chemoradiotherapy. Those who did not understand Thai language, had other cancers (except for skin cancer), were diagnosed with impaired cognition and/or overt psychosis, and major depression were excluded. The FACT-CX comprises 42 items with 5 domains and a score range of 0-168. The WHOQOL-BREF comprises 26 items with 4 domains and a score range of 26-130. The participants were interviewed about demographic and clinical data. Both questionnaires were self-completed. Factor analysis was used to compare our data with the previous structure. The reliability used Cronbach's alpha. Spearman's correlation determined relationship between the domains of the modified FACT-CX and WHOQOL-BREF. Both questionnaires were compared with socioeconomic and clinical variables using the Ranksum test and Kruskal-Wallis test. P-value > 0.05 considered significant.

Results: The 245 participants included. Expletory factor analysis revealed an accumulative variance of 0.42 with 4 factors. The internal consistency was 0.84, 0.81, 0.78, 0.77 and 0.90 for perception of self, suffering symptoms, family support, life resilience and total questions. There was correlation between the domains of the modified FACT-CX and WHOQOL-BREF. Both the modified FACT-CX and WHOQOL-BREF could identify differences between the groups of patients.

Conclusion: Finally, the Thai modified FACT-CX was found to be reliable and valid for measuring quality of life among untreated cervical cancer patients.<br />.

Keywords: Cervical cancer; FACT-CX; Quality of Life; Validation.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Relationship between Number of Factor and Eigenvalue. FA; Factor analysis
Figure 2
Figure 2
Correlation Matrix between Domain in Modified FACT-CX and WHOQOL-BREF. The statistic calculated by Spearman’s correlation. *** p ≤ 0.001; Abbrivation: PS, Perception to self; SS, Suffering symptom (SS); FS, Phychological well-being; SR, Social relationship; SE, Satisfaction with the environment; WHO, overall score of WHOQOL-BREF
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Anna BC, Jason WO. Best practices in exploratory factor analysis: four recommendations for getting the most from your analysis: Practical Assessment Research and Evaluation. 2005. pp. 10–7. Available online: http://pareonline.net/getvn.asp?v=10&amp;n=7.
    1. Calaguas MJ, Gubat JA. South East Asia, Differing socioeconomic factors, differing access to radiotherapy: The Philippines, a Microcosm. Semin Radiat Oncol. 2017;27:176–83. - PubMed
    1. Ding Y, Hu Y, Hallberg IR. Psychometric properties of the Chinese version of the functional assessment of cancer therapy-cervix (FACT-Cx) measuring health-related quality of life. Health Qual Life Outcomes. 2012;10:124. - PMC - PubMed
    1. Fregnani CM, Fregnani JH, Dias de Oliveira Latorre Mdo R, de Almeida AM. Evaluation of the psychometric properties of the Functional Assessment of Cancer Therapy-Cervix questionnaire in Brazil. PLoS One. 2013;8:e77947. - PMC - PubMed
    1. Gillan C, Abrams D, Harnett N, Wiljer D, Catton P. Fears and misperceptions of radiation therapy: sources and impact on decision-making and anxiety. J Cancer Edu. 2014;29:289–95. - PubMed

Publication types