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Review
. 2020 Aug 18;38(37):5896-5904.
doi: 10.1016/j.vaccine.2020.07.005. Epub 2020 Jul 24.

Preventing infectious diseases for healthy ageing: The VITAL public-private partnership project

Debbie Van Baarle  1 , Kaatje Bollaerts  2 , Giuseppe Del Giudice  3 , Stephen Lockhart  4 , Christine Luxemburger  5 , Maarten J Postma  6 , Aura Timen  7 , Baudouin Standaert  8 ; Vaccines, Infectious Diseases in the Ageing Population (VITAL) consortium
Affiliations
Review

Preventing infectious diseases for healthy ageing: The VITAL public-private partnership project

Debbie Van Baarle et al. Vaccine. .

Abstract

Prevention of infectious diseases through immunisation of the growing ageing adult population is essential to improve healthy ageing. However, many licenced and recommended vaccines for this age group show signs of waning of the protective effect due to declining immune responses (immuno-senescence) and decreasing vaccine uptake. Today's major challenge is to improve vaccine effectiveness and uptake and to deploy efficient vaccination strategies for this age group. The Vaccines and InfecTious diseases in the Ageing popuLation (VITAL) project, with partners from 17 academic & research groups and public institutes as well as seven industry collaborators, aims to address this challenge. The ambition is to provide evidence-based knowledge to local decision makers. Using a holistic and multidisciplinary approach and novel analytical methods, VITAL will provide tools that allow the development of targeted immunisation programs for ageing adults in European countries. The project is based on four pillars focussing on the assessment of the burden of vaccine-preventable diseases in ageing adults, the dissection of the mechanisms underlying immuno-senescence, the analysis of the clinical and economic public health impact of vaccination strategies and the development of educational resources for healthcare professionals. By the end of the project, a clear, detailed, and integrated program should be available for implementing a consistent, affordable, and sustainable vaccination strategy for ageing adults with regular evaluations of its impact over time.

Keywords: Elderly; Immuno-senescence; Infectious diseases; Public health; Public-private partnership; Vaccine.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Giuseppe Del Giudice and Baudouin Standaert are employees and shareholders of the GSK group of companies, Stephen Lockhart is an employee and shareholder of Pfizer, and Christine Luxemburger is an employee and shareholder of Sanofi.

Figures

Fig. 1
Fig. 1
WP1 (green boxes) and working with the other WPs of VITAL. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 2
Fig. 2
Identifying the different tasks of WP2.
Fig. 3
Fig. 3
Specifying the different baskets with specific tasks of WP3.
Fig. 4
Fig. 4
Tasks of WP4.
See this image and copyright information in PMC

References

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