Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

Christoph F Dietrich¹, Christian Pállson Nolsøe², Richard G Barr³, Annalisa Berzigotti⁴, Peter N Burns⁵, Vito Cantisani⁶, Maria Cristina Chammas⁷, Nitin Chaubal⁸, Byung Ihn Choi⁹, Dirk-André Clevert¹⁰, Xinwu Cui¹¹, Yi Dong¹², Mirko D'Onofrio¹³, J Brian Fowlkes¹⁴, Odd Helge Gilja¹⁵, Pintong Huang¹⁶, Andre Ignee¹⁷, Christian Jenssen¹⁸, Yuko Kono¹⁹, Masatoshi Kudo²⁰, Nathalie Lassau²¹, Won Jae Lee²², Jae Young Lee²³, Ping Liang²⁴, Adrian Lim²⁵, Andrej Lyshchik²⁶, Maria Franca Meloni²⁷, Jean Michel Correas²⁸, Yasunori Minami²⁹, Fuminori Moriyasu³⁰, Carlos Nicolau³¹, Fabio Piscaglia³², Adrian Saftoiu³³, Paul S Sidhu³⁴, Ioan Sporea³⁵, Guido Torzilli³⁶, Xiaoyan Xie³⁷, Rongqin Zheng³⁸

Affiliations

¹ Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland; Johann Wolfgang Goethe Universitätsklinik, Frankfurt, Germany. Electronic address: c.f.dietrich@googlemail.com.
² Center for Surgical Ultrasound, Dep of Surgery, Zealand University Hospital, Køge. Copenhagen Academy for Medical Education and Simulation (CAMES). University of Copenhagen, Denmark.
³ Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio, USA; Southwoods Imaging, Youngstown, Ohio, USA.
⁴ Hepatology, University Clinic for Visceral Surgery and Medicine, DBMR, Inselspital, University of Bern, Switzerland.
⁵ Department of Medical Biophysics, University of Toronto, Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada.
⁶ Uos Ecografia Internistico-chirurgica, Dipartimento di Scienze Radiologiche, Oncologiche, Anatomo-Patologiche, Policlinico Umberto I, Univ. Sapienza, Rome, Italy.
⁷ Institute of Radiology, Hospital das Clínicas, School of Medicine, University of São Paulo, Brazil.
⁸ Thane Ultrasound Centre, Jaslok Hospital and Research Centre, Mumbai, India.
⁹ Department of Radiology, Chung-Ang University Hospital, Seoul, Korea.
¹⁰ Interdisciplinary Ultrasound-Center, Department of Radiology, University of Munich-Grosshadern Campus, Munich, Germany.
¹¹ Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹² Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
¹³ Department of Radiology, G. B. Rossi University Hospital, University of Verona, Verona, Italy.
¹⁴ Basic Radiological Sciences Division, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
¹⁵ National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, and Department of Clinical Medicine, University of Bergen, Norway.
¹⁶ Department of Ultrasound in Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
¹⁷ Department of Internal Medicine 2, Caritas Krankenhaus, Bad Mergentheim, Germany.
¹⁸ Krankenhaus Märkisch Oderland, Department of Internal Medicine, Strausberg/Wriezen, Germany.
¹⁹ Departments of Medicine and Radiology, University of California, San Diego, California, USA.
²⁰ Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
²¹ Imaging Department, Gustave Roussy and BIOMAPS, Université Paris-Saclay, Villejuif, France.
²² Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Departments of Health and Science and Technology and Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Korea.
²³ Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
²⁴ Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China.
²⁵ Department of Imaging, Imperial College London and Healthcare NHS Trust, Charing Cross Hospital Campus, London, United Kingdom.
²⁶ Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
²⁷ Radiology Department, University of Pavia, Milan, Italy.
²⁸ Service de Radiologie Adultes, Hôpital Necker, Université Paris Descartes, Paris, France.
²⁹ Department of Gastroenterology and Hepatology, Faculty of Medicine, Kindai University, Osaka, Japan.
³⁰ Center for Cancer Ablation Therapy, Sanno Hospital, International University of Health and Welfare, Tokyo, Japan.
³¹ Radiology Department, Hospital Clinic. University of Barcelona, Barcelona, Spain.
³² Unit of Internal Medicine, Department of Medical and Surgical Sciences, University of Bologna S. Orsola-Malpighi Hospital, Bologna, Italy.
³³ Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Romania.
³⁴ Department of Radiology, King's College Hospital, King's College London, London, United Kingdom.
³⁵ Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
³⁶ Department of Surgery, Division of Hepatobiliary & General Surgery, Humanitas University & Research Hospital, Rozzano, Milan, Italy.
³⁷ Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
³⁸ Department of Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

PMID: 32713788
DOI: 10.1016/j.ultrasmedbio.2020.04.030

Practice Guideline

Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

Christoph F Dietrich et al. Ultrasound Med Biol. 2020 Oct.

. 2020 Oct;46(10):2579-2604.

doi: 10.1016/j.ultrasmedbio.2020.04.030. Epub 2020 Jul 24.

Authors

Affiliations

¹ Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland; Johann Wolfgang Goethe Universitätsklinik, Frankfurt, Germany. Electronic address: c.f.dietrich@googlemail.com.
² Center for Surgical Ultrasound, Dep of Surgery, Zealand University Hospital, Køge. Copenhagen Academy for Medical Education and Simulation (CAMES). University of Copenhagen, Denmark.
³ Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio, USA; Southwoods Imaging, Youngstown, Ohio, USA.
⁴ Hepatology, University Clinic for Visceral Surgery and Medicine, DBMR, Inselspital, University of Bern, Switzerland.
⁵ Department of Medical Biophysics, University of Toronto, Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada.
⁶ Uos Ecografia Internistico-chirurgica, Dipartimento di Scienze Radiologiche, Oncologiche, Anatomo-Patologiche, Policlinico Umberto I, Univ. Sapienza, Rome, Italy.
⁷ Institute of Radiology, Hospital das Clínicas, School of Medicine, University of São Paulo, Brazil.
⁸ Thane Ultrasound Centre, Jaslok Hospital and Research Centre, Mumbai, India.
⁹ Department of Radiology, Chung-Ang University Hospital, Seoul, Korea.
¹⁰ Interdisciplinary Ultrasound-Center, Department of Radiology, University of Munich-Grosshadern Campus, Munich, Germany.
¹¹ Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹² Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
¹³ Department of Radiology, G. B. Rossi University Hospital, University of Verona, Verona, Italy.
¹⁴ Basic Radiological Sciences Division, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
¹⁵ National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, and Department of Clinical Medicine, University of Bergen, Norway.
¹⁶ Department of Ultrasound in Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
¹⁷ Department of Internal Medicine 2, Caritas Krankenhaus, Bad Mergentheim, Germany.
¹⁸ Krankenhaus Märkisch Oderland, Department of Internal Medicine, Strausberg/Wriezen, Germany.
¹⁹ Departments of Medicine and Radiology, University of California, San Diego, California, USA.
²⁰ Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
²¹ Imaging Department, Gustave Roussy and BIOMAPS, Université Paris-Saclay, Villejuif, France.
²² Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Departments of Health and Science and Technology and Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Korea.
²³ Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
²⁴ Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China.
²⁵ Department of Imaging, Imperial College London and Healthcare NHS Trust, Charing Cross Hospital Campus, London, United Kingdom.
²⁶ Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
²⁷ Radiology Department, University of Pavia, Milan, Italy.
²⁸ Service de Radiologie Adultes, Hôpital Necker, Université Paris Descartes, Paris, France.
²⁹ Department of Gastroenterology and Hepatology, Faculty of Medicine, Kindai University, Osaka, Japan.
³⁰ Center for Cancer Ablation Therapy, Sanno Hospital, International University of Health and Welfare, Tokyo, Japan.
³¹ Radiology Department, Hospital Clinic. University of Barcelona, Barcelona, Spain.
³² Unit of Internal Medicine, Department of Medical and Surgical Sciences, University of Bologna S. Orsola-Malpighi Hospital, Bologna, Italy.
³³ Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Romania.
³⁴ Department of Radiology, King's College Hospital, King's College London, London, United Kingdom.
³⁵ Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
³⁶ Department of Surgery, Division of Hepatobiliary & General Surgery, Humanitas University & Research Hospital, Rozzano, Milan, Italy.
³⁷ Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
³⁸ Department of Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

PMID: 32713788
DOI: 10.1016/j.ultrasmedbio.2020.04.030

Abstract

The present, updated document describes the fourth iteration of recommendations for the hepatic use of contrast-enhanced ultrasound, first initiated in 2004 by the European Federation of Societies for Ultrasound in Medicine and Biology. The previous updated editions of the guidelines reflected changes in the available contrast agents and updated the guidelines not only for hepatic but also for non-hepatic applications. The 2012 guideline requires updating as, previously, the differences in the contrast agents were not precisely described and the differences in contrast phases as well as handling were not clearly indicated. In addition, more evidence has been published for all contrast agents. The update also reflects the most recent developments in contrast agents, including U.S. Food and Drug Administration approval and the extensive Asian experience, to produce a truly international perspective. These guidelines and recommendations provide general advice on the use of ultrasound contrast agents (UCAs) and are intended to create standard protocols for the use and administration of UCAs in liver applications on an international basis to improve the management of patients.

Keywords: Contrast-enhanced ultrasound; Guideline; Liver; World Federation for Ultrasound in Medicine and Biology.

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Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

Affiliations

Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

Authors

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Abstract

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Medical