Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Aug;31(8):1655-1657.
doi: 10.1681/ASN.2020060844. Epub 2020 Jul 23.

No Zoom Required: Meeting at the β-Intercalated Cells

Wie-Yin Lin  1 , Shmuel Muallem  2
Affiliations
Editorial

No Zoom Required: Meeting at the β-Intercalated Cells

Wie-Yin Lin et al. J Am Soc Nephrol. 2020 Aug.
No abstract available

Keywords: CFTR; bicarbonate; excretion; pendrin.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Interaction with and regulation of the SLC26 transporters by CFTR. The structures of the unphosphorylated CFTR (5UAK) and the phosphorylated CFTR (6MSM) were taken from Zhang et al., and of Slc26a9 (6RTF) from Walter et al. In the inactive state, the R domain of CFTR prevents the interaction of the NBDs and is not available for interaction with other proteins. The basal activity of the SLC26 transporters, including pendrin, is low with the two STAS domains of the two monomers interacting with each other. An increase in cAMP and activation of PKA phosphorylates the R domain, resulting in the swinging of the R domain and its interaction with the STAS domain, which can facilitate and stabilize the interaction of the nucleotide binding clefts to activate CFTR. Interaction of the R domain with the STAS domain stabilizes expression and activates the SLC26 transporters. NBD, nucleotide binding domain; TMD, transmembrane domain.
See this image and copyright information in PMC

Comment on

  • Impaired Renal HCO3- Excretion in Cystic Fibrosis.
    Berg P, Svendsen SL, Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J. Berg P, et al. J Am Soc Nephrol. 2020 Aug;31(8):1711-1727. doi: 10.1681/ASN.2020010053. Epub 2020 Jul 23. J Am Soc Nephrol. 2020. PMID: 32703846 Free PMC article.

References

    1. Seifter JL: Body fluid compartments, cell membrane ion transport, electrolyte concentrations, and acid-base balance. Semin Nephrol 39: 368–379, 2019. - PubMed
    1. Wall SM, Verlander JW, Romero CA: The renal physiology of pendrin-positive intercalated cells. Physiol Rev 100: 1119–1147, 2020. - PMC - PubMed
    1. Lee MG, Ohana E, Park HW, Yang D, Muallem S: Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev 92: 39–74, 2012. - PMC - PubMed
    1. Viteri AL, Poppell JW, Lasater JM, Dyck WP: Renal response to secretin. J Appl Physiol 38: 661–664, 1975. - PubMed
    1. Berg P, S.L.S., Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J: Impaired renal HCO3- excretion in cystic fibrosis. J Am Soc Nephrol 31: 1711–1727, 2020 - PMC - PubMed

Substances