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. 2020 Jul 23;9(8):439.
doi: 10.3390/antibiotics9080439.

Prescription of Levofloxacin and Moxifloxacin in Select Hospitals in Uganda: A Pilot Study to Assess Guideline Concordance

Victoria Nambasa  1 , Helen B Ndagije  1 , Allan Serwanga  1 , Leonard Manirakiza  1 , Joanitah Atuhaire  1 , Diana Nakitto  1 , Ronald Kiguba  2 , Albert Figueras  3
Affiliations

Prescription of Levofloxacin and Moxifloxacin in Select Hospitals in Uganda: A Pilot Study to Assess Guideline Concordance

Victoria Nambasa et al. Antibiotics (Basel). .

Abstract

Background: In Uganda, national tuberculosis (TB) treatment guidelines were revised to include the newer generation fluoroquinolones among the second-line treatment options for multidrug-resistant TB. This study was designed to analyze if the prescription of these quinolones is compliant with country recommendations. Methods: This was an observational retrospective study of consumption data for 2017 and 2018 across four selected regional referral hospitals. The sources of consumption data were hospital pharmacy stock cards and the dispensing register. The medical files of patients who had been prescribed fluoroquinolones were also assessed to study compliance with the Uganda Clinical Guidelines and the British National Formulary (BNF). Results: None of the 371 levofloxacin prescriptions analyzed complied with the Uganda Clinical Guidelines, although 250 (67.3%) were prescribed for indications included in the BNF. According to WHO prescription indicators, only 220 (59.3%) prescriptions were appropriate. Conclusion: The prescription of levofloxacin and moxifloxacin increased in the hospitals studied, but in a high proportion of cases, they were not compliant with country recommendations. The findings call for the strengthening of national antimicrobial stewardship programs.

Keywords: drug utilization study; fluoroquinolones; multidrug-resistant tuberculosis; prescription habits.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Proportion (%) of inappropriate prescriptions according to each WHO indicator (see Methods) and hospital: Eastern Regional Reference Hospital (ERRH), Central Regional Reference Hospital (CRRH), South Western Regional Reference Hospital (SWRRH), and Western Regional Reference Hospital (WRRH).
See this image and copyright information in PMC

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