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. 2020 Jul 23;26(4):171-178.
doi: 10.4103/sjg.SJG_201_20. Online ahead of print.

The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis

Jie Tan  1 , Jian Zhang  2 , Zhenzhen Zhao  3 , Jie Zhang  4 , Mengzhen Dong  4 , Xuefeng Ma  4 , Shousheng Liu  3 , Yongning Xin  5
Affiliations

The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis

Jie Tan et al. Saudi J Gastroenterol. .

Abstract

Background/aims: : The role of two polymorphisms rs1800591 and rs3816873 of the microsomal triglyceride transfer protein (MTTP) gene in the development of nonalcoholic fatty liver disease (NAFLD) remains controversial. A meta-analysis was conducted to determine the correlation between these MTTP polymorphisms and NAFLD.

Materials and methods: : A systematic search was carried out using PubMed, Embase, and Cochrane Library to retrieve English studies that reported the relationship between MTTP polymorphisms (rs1800591 and rs3816873) and NAFLD published before February 18, 2020. Odds ratio (OR) and 95% confidence interval (CI) were used to appraise the risk of MTTP polymorphism in NAFLD.

Results: : A total of 10 case-control studies, including 1388 cases and 1690 healthy subjects, were included. No significant correlation between the rs1800591 (G vs. T: OR = 1.08, 95% CI = 0.68-1.70, P = 0.76) and rs3816873 (CT + CC vs. TT: OR = 1.23, 95% CI = 0.76-2.01, P = 0.398) polymorphisms of MTTP and NAFLD was found in any of the models. However, when NASH patients confirmed by liver biopsy were extracted alone for rs1800591 polymorphism analysis, it was found that the G allele significantly increased the risk of NASH under the heterozygote model (GT vs. TT: OR = 3.16, 95% CI = 1.13-8.83, P = 0.028) and dominant model (GT + GG vs. TT: OR = 3.03, 95% CI = 1.13-8.09, P = 0.027).

Conclusion: The present meta-analysis revealed that the rs1800591 and rs3816873 polymorphisms of the MTTP gene are uncommon in NAFLD. However, the G allele of rs1800591 was more likely to be correlated to NASH susceptibility.

Keywords: MTTP; Meta-analysis; NAFLD; polymorphism.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Flow diagram of the eligible study selection process
Figure 2
Figure 2
Forest plots for the association between MTTP rs1800591 and rs3816873 polymorphisms and susceptibility to NAFLD. (a) Allelic model (rs1800591 polymorphism): G vs. T. (b) Heterozygous model (rs3816873 polymorphism): CT vs. TT
Figure 3
Figure 3
Forest plots for the association between MTTP rs1800591 xspolymorphism and NASH risk under the (a) heterozygous model (GT vs. TT) and (b) dominant model (GT + GG vs. TT)
Figure 4
Figure 4
Begg's funnel plot and Egger's linear regression plot for detecting the publication bias through the recessive model. (a) Begg's funnel plot for the rs1800591 polymorphism; (b) Egger's linear regression plot for the rs1800591 polymorphism; (c) Begg's funnel plot for the rs3816873 polymorphism; (d) Egger's linear regression plot for the rs3816873 polymorphism
See this image and copyright information in PMC

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