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. 2021 Jan;44(1):88-97.
doi: 10.1038/s41440-020-0521-2. Epub 2020 Jul 27.

Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria

Eikan Mishima #  1 , Yukino Funayama #  2 , Takehiro Suzuki  3 , Fumiko Mishima  4 , Fumihiko Nitta  4 , Takafumi Toyohara  3 , Koichi Kikuchi  3 , Hiroshi Kunikata  4 , Junichiro Hashimoto  5 , Mariko Miyazaki  3 , Hideo Harigae  3   6 , Toru Nakazawa  4 , Sadayoshi Ito  3   7 , Takaaki Abe  8   9   10
Affiliations

Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria

Eikan Mishima et al. Hypertens Res. 2021 Jan.

Abstract

Malignant hypertension, a form of hypertensive emergency, causes acute damage in vital organs such as the brain, eyes, and kidneys. We aimed to examine the concurrency of acute hypertensive damage across the target organs to elucidate the underlying analogous pathophysiology. This single-center retrospective study evaluated the characteristics of organ damage, short-term clinical course, and interorgan relationships in patients with malignant hypertension treated between 2008 and 2019. Baseline characteristics of 20 patients who met our inclusion criteria were mean age 48 ± 13 years and blood pressure 222 ± 18/142 ± 16 mmHg; the median estimated glomerular filtration rate and urinary protein level were 49 mL/min/1.73 m2 (interquartile range [IQR] 27-79) and 1.9 g/g creatinine (IQR 0.2-4.0), respectively. Posterior reversible encephalopathy syndrome (PRES) was found in 60% of patients with major involvement and a wide variety of distribution patterns in the brainstem. In the fundus, serous retinal detachment was found in 60% of patients. Patients with PRES and serous retinal detachment showed higher levels of urinary protein than those without symptoms (P = 0.007 and 0.02, respectively), and proteinuria >1 g/g creatinine highly complicated both PRES and serous retinal detachment (91%). Matrix analysis also showed that the three symptoms were highly associated with each other. These results demonstrate the close relationship and concurrency of hypertensive acute organ damage in the brain, eyes, and kidneys. A common analogous mechanism, such as hyperperfusion-induced capillary leakage in each organ, implies an underlying pathophysiology of PRES, serous retinal detachment, and proteinuria.

Keywords: Hypertensive emergency; Hypertensive retinopathy; Posterior reversible encephalopathy syndrome (PRES); Serous retinal detachment; Thrombotic microangiopathy.

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