[Differences in the reaction of the mucosa of the gastric fundus and pylorus to high concentration of ethanol]

Abstract

Histopathological morphometric analysis were made to determine the degree and extent of the stomach mucosa lesions in fundus and antrum of 36 rats after 15 min., 1, 24 and 96 hours after ethanol insult. At the early stage the intensity of the lesion caused by direct influence of ethanol was in both parts similar. Evident differences occurred after 1 hour, and especially after 24 hours, and were caused by secondary, endogenous agents. Among them the most important seems to be the specificity of the vascular net reaction to alcohol stimulus in each part of the stomach, differences in secretion intensity and composition of the superficial mucosal gel, as well as in the contents of some active substances.