The ENIGMA sports injury working group:- an international collaboration to further our understanding of sport-related brain injury

Inga K Koerte^{1

2}, Carrie Esopenko^{3

4}, Sidney R Hinds 2nd^{5

6}, Martha E Shenton^{7

5}, Elena M Bonke^{8

9}, Jeffrey J Bazarian¹⁰, Kevin C Bickart^{11

12}, Erin D Bigler^{13

14

15}, Sylvain Bouix⁷, Thomas A Buckley^{16

17}, Meeryo C Choe^{11

18}, Paul S Echlin¹⁹, Jessica Gill²⁰, Christopher C Giza^{11

18

21}, Jasmeet Hayes^{22

23}, Cooper B Hodges^{13

14

24}, Andrei Irimia^{25

26}, Paula K Johnson^{13

15}, Kimbra Kenney^{5

27}, Harvey S Levin^{28

29}, Alexander P Lin³⁰, Hannah M Lindsey^{13

14

24}, Michael L Lipton^{31

32}, Jeffrey E Max^{33

34}, Andrew R Mayer^{35

36}, Timothy B Meier³⁷, Kian Merchant-Borna¹⁰, Tricia L Merkley^{13

14

15}, Brian D Mills³⁸, Mary R Newsome^{28

29}, Tara Porfido⁴, Jaclyn A Stephens³⁹, Maria Carmela Tartaglia^{40

41

42}, Ashley L Ware⁴³, Ross D Zafonte⁴⁴, Michael M Zeineh³⁸, Paul M Thompson^{45

46}, David F Tate^{13

24}, Emily L Dennis^{13

24}, Elisabeth A Wilde^{13

24

28}, David Baron⁴⁷

Affiliations

¹ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Waltherstr. 23, 80337, Munich, Germany. Inga.Koerte@med.lmu.de.
² Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Inga.Koerte@med.lmu.de.
³ Department of Rehabilitation and Movement Science, Rutgers Biomedical Health Sciences, Newark, NJ, USA.
⁴ School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, NJ, USA.
⁵ Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
⁶ VA Boston Healthcare System, Boston, MA, USA.
⁷ Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁸ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Waltherstr. 23, 80337, Munich, Germany.
⁹ Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University, Munich, Germany.
¹⁰ Departments of Emergency Medicine & Neurology, University of Rochester School of Medicine, Rochester, NY, USA.
¹¹ UCLA Steve Tisch BrainSPORT Program, Los Angeles, CA, USA.
¹² Neurology and Neuropsychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹³ Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹⁴ Department of Psychology, Brigham Young University, Provo, UT, USA.
¹⁵ Neuroscience Center, Brigham Young University, Provo, UT, USA.
¹⁶ Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
¹⁷ Biomechanics and Movement Science Program, University of Delaware, Newark, DE, USA.
¹⁸ Department of Pediatrics, Division of Neurology, UCLA Mattel Children's Hospital, Los Angeles, CA, USA.
¹⁹ Elliott Sports Medicine Clinic, Burlington, ON, Canada.
²⁰ Department of Intramural Research, National Institutes of Health, Bethesda, MD, USA.
²¹ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
²² Psychology Department, The Ohio State University, Columbus, OH, USA.
²³ Chronic Brain Injury Program, The Ohio State University, Columbus, OH, USA.
²⁴ George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.
²⁵ Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
²⁶ Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
²⁷ National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA.
²⁸ H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
²⁹ Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
³⁰ Center for Clinical Spectroscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³¹ Departments of Radiology, Psychiatry and Behavioral Sciences and The Dominick P. Purpura Department of Neuroscience, The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.
³² Department of Radiology, Montefiore Medicine, Bronx, NY, USA.
³³ Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
³⁴ Department of Psychiatry, Rady Children's Hospital, San Diego, CA, USA.
³⁵ Mind Research Network, Albuquerque, NM, USA.
³⁶ Departments of Neurology and Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA.
³⁷ Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
³⁸ Department of Radiology, Stanford University, Stanford, CA, USA.
³⁹ Department of Occupational Therapy, Colorado State University, Fort Collins, CO, USA.
⁴⁰ Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
⁴¹ University Health Network, Toronto, ON, Canada.
⁴² Krembil Brain Institute, Toronto, ON, Canada.
⁴³ Department of Psychology, University of Calgary, Calgary, Alberta, Canada.
⁴⁴ Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.
⁴⁵ Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA.
⁴⁶ Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA, USA.
⁴⁷ Western University of Health Sciences, Pomona, CA, USA.

PMID: 32720179
PMCID: PMC7855299
DOI: 10.1007/s11682-020-00370-y

The ENIGMA sports injury working group:- an international collaboration to further our understanding of sport-related brain injury

Inga K Koerte et al. Brain Imaging Behav. 2021 Apr.

. 2021 Apr;15(2):576-584.

doi: 10.1007/s11682-020-00370-y.

Authors

Affiliations

¹ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Waltherstr. 23, 80337, Munich, Germany. Inga.Koerte@med.lmu.de.
² Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Inga.Koerte@med.lmu.de.
³ Department of Rehabilitation and Movement Science, Rutgers Biomedical Health Sciences, Newark, NJ, USA.
⁴ School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, NJ, USA.
⁵ Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
⁶ VA Boston Healthcare System, Boston, MA, USA.
⁷ Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁸ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Waltherstr. 23, 80337, Munich, Germany.
⁹ Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University, Munich, Germany.
¹⁰ Departments of Emergency Medicine & Neurology, University of Rochester School of Medicine, Rochester, NY, USA.
¹¹ UCLA Steve Tisch BrainSPORT Program, Los Angeles, CA, USA.
¹² Neurology and Neuropsychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹³ Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹⁴ Department of Psychology, Brigham Young University, Provo, UT, USA.
¹⁵ Neuroscience Center, Brigham Young University, Provo, UT, USA.
¹⁶ Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
¹⁷ Biomechanics and Movement Science Program, University of Delaware, Newark, DE, USA.
¹⁸ Department of Pediatrics, Division of Neurology, UCLA Mattel Children's Hospital, Los Angeles, CA, USA.
¹⁹ Elliott Sports Medicine Clinic, Burlington, ON, Canada.
²⁰ Department of Intramural Research, National Institutes of Health, Bethesda, MD, USA.
²¹ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
²² Psychology Department, The Ohio State University, Columbus, OH, USA.
²³ Chronic Brain Injury Program, The Ohio State University, Columbus, OH, USA.
²⁴ George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.
²⁵ Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
²⁶ Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
²⁷ National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA.
²⁸ H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
²⁹ Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
³⁰ Center for Clinical Spectroscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³¹ Departments of Radiology, Psychiatry and Behavioral Sciences and The Dominick P. Purpura Department of Neuroscience, The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.
³² Department of Radiology, Montefiore Medicine, Bronx, NY, USA.
³³ Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
³⁴ Department of Psychiatry, Rady Children's Hospital, San Diego, CA, USA.
³⁵ Mind Research Network, Albuquerque, NM, USA.
³⁶ Departments of Neurology and Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA.
³⁷ Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
³⁸ Department of Radiology, Stanford University, Stanford, CA, USA.
³⁹ Department of Occupational Therapy, Colorado State University, Fort Collins, CO, USA.
⁴⁰ Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
⁴¹ University Health Network, Toronto, ON, Canada.
⁴² Krembil Brain Institute, Toronto, ON, Canada.
⁴³ Department of Psychology, University of Calgary, Calgary, Alberta, Canada.
⁴⁴ Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.
⁴⁵ Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA.
⁴⁶ Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA, USA.
⁴⁷ Western University of Health Sciences, Pomona, CA, USA.

PMID: 32720179
PMCID: PMC7855299
DOI: 10.1007/s11682-020-00370-y

Abstract

Sport-related brain injury is very common, and the potential long-term effects include a wide range of neurological and psychiatric symptoms, and potentially neurodegeneration. Around the globe, researchers are conducting neuroimaging studies on primarily homogenous samples of athletes. However, neuroimaging studies are expensive and time consuming, and thus current findings from studies of sport-related brain injury are often limited by small sample sizes. Further, current studies apply a variety of neuroimaging techniques and analysis tools which limit comparability among studies. The ENIGMA Sports Injury working group aims to provide a platform for data sharing and collaborative data analysis thereby leveraging existing data and expertise. By harmonizing data from a large number of studies from around the globe, we will work towards reproducibility of previously published findings and towards addressing important research questions with regard to diagnosis, prognosis, and efficacy of treatment for sport-related brain injury. Moreover, the ENIGMA Sports Injury working group is committed to providing recommendations for future prospective data acquisition to enhance data quality and scientific rigor.

Keywords: Concussion; ENIGMA; Repetitive head impacts; Sport-related brain injury.

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Figures

**Fig. 1**
Multi-stage disease model of short- and long-term consequence following sport-related brain injury (adapted from Koerte et al. Brain Pathology, 2015). Quality of life is indicated by symptom load, which is expressed as a function of time, thereby allowing for the differentiation between at least three main trajectories of the disease including an acute/subacute phase, a chronic/static phase, and a phase of possible neurodegeneration

See this image and copyright information in PMC

References

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The ENIGMA sports injury working group:- an international collaboration to further our understanding of sport-related brain injury

Affiliations

The ENIGMA sports injury working group:- an international collaboration to further our understanding of sport-related brain injury

Authors

Affiliations

Abstract

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous