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. 2020 Nov/Dec;27(6):e620-e621.
doi: 10.1097/MJT.0000000000000993.

Fluconazole Increases Ibrutinib Concentration

Takeo Yasu  1 , Kenji Momo  1 , Seiichirou Kuroda  1 , Toyotaka Kawamata  2
Affiliations

Fluconazole Increases Ibrutinib Concentration

Takeo Yasu et al. Am J Ther. 2020 Nov/Dec.
No abstract available

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References

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    1. Imbruvica®. Prescribing information. Available at: https://www.janssenmd.com/pdf/imbruvica/imbruvica_pi.pdf. Accessed October 17, 2018.
    1. Varhe A, Olkkola KT, Neuvonen PJ. Effect of fluconazole dose on the extent of fluconazole-triazolam interaction. Br J Clin Pharmacol. 1996;42:465–470.
    1. Isoherranen N, Ludington SR, Givens RC, et al. The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation. Drug Metab Dispos. 2008;36:146–154.
    1. Yasu T, Momo K, Yasui H, et al. Simple determination of plasma ibrutinib concentration using high-performance liquid chromatography. Biomed Chromatogr. 2019;33:e4435.

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