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Editorial
. 2020 Oct;63(4):405-407.
doi: 10.1165/rcmb.2020-0260ED.

Repair of the Lung by Regulatory T Cells

Ellyse M Cipolla  1 , John F Alcorn  1
Affiliations
Editorial

Repair of the Lung by Regulatory T Cells

Ellyse M Cipolla et al. Am J Respir Cell Mol Biol. 2020 Oct.
No abstract available

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Figures

Figure 1.
Figure 1.
Regulatory T-cell (Treg) control of alveolar repair following acute lung injury (ALI). In the context of LPS-induced ALI in a preclinical animal model, recovery from inflammation and lung repair requires Tregs. In the presence of Tregs, epithelial and endothelial proliferation result in repair of alveolar structure. In the absence of Tregs, these processes are deregulated, resulting in increased inflammatory macrophage persistence, edema, and epithelial damage. The alveolar type II gene-expression signature suggests elevated IFN signaling in the absence of Tregs. IFNγ neutralization in the presence of Tregs results in increased antiinflammatory alveolar-macrophage presence and improves lung repair. Importantly, in the absence of Tregs, IFNγ plays a significant detrimental role in ALI recovery. Neutralization of IFNγ in this setting improves epithelial-cell proliferation, resolution of inflammation, and repair. The image was made in BioRender (biorender.com).
See this image and copyright information in PMC

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References

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