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Comparative Study
. 1988 Apr;1(2):127-32.
doi: 10.1016/0896-6273(88)90196-1.

Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human

K S Kosik  1 , L D Orecchio, G A Bruns, L I Benowitz, G P MacDonald, D R Cox, R L Neve
Affiliations
Comparative Study

Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human

K S Kosik et al. Neuron. 1988 Apr.

Abstract

The growth-associated protein (GAP-43) is considered a crucial component of an effective regenerative response in the nervous system. Its phosphorylation by protein kinase C correlates with long-term potentiation. Sequence analysis of human cDNAs coding for this protein shows that the human GAP-43 gene is highly homologous to the rat gene; this homology extends into the 3'-untranslated region. However, the human protein contains a 10 amino acid insert. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16.

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