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. 2020 Mar;59(1):55-62.
doi: 10.20471/acc.2020.59.01.07.

NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS AN EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN NEWBORNS

Silvana Naunova-Timovska  1 , Svetlana Cekovska  1 , Emilija Sahpazova  1 , Velibor Tasić  1
Affiliations

NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS AN EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN NEWBORNS

Silvana Naunova-Timovska et al. Acta Clin Croat. 2020 Mar.

Abstract

The aim of the study was to determine the incidence, risk factors and efficiency of the neutrophil gelatinase-associated lipocalin (NGAL) biomarker in early diagnosis of acute kidney injury (AKI) in newborns. The study was designed as a prospective, clinical, epidemiological investigation conducted in the period of three years, which included 50 newborns with AKI hospitalized in the Neonatal Intensive Care Unit, University Children's Hospital in Skopje. The estimated prevalence of AKI was 6.4%, while the prevalence according to RIFLE classification was 8.7%. Perinatal asphyxia was a common predisposing factor associated to kidney injury. The mortality rate was 32% and was significantly higher in the group of newborns with congenital heart diseases. There was a significant difference between NGAL values and creatinine values on the day of admission. There was a significant difference in NGAL values between newborns with AKI and lethal outcome and newborns without lethal outcome (p<0.001). In conclusion, AKI is a life-threatening condition. It is an independent contributor to mortality. Urinary NGAL is an early predictive biomarker of AKI in critically ill newborns.

Keywords: Acute kidney injury; Biomarkers; Early diagnosis; Infant, newborn; Lipocalin-2; Risk factors.

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Figures

Fig. 1
Fig. 1
Predisposing factors for acute kidney injury according to gender. MAS = meconium aspiration syndrome
Fig. 2
Fig. 2
Distribution of mortality according to predisposing factors associated with acute kidney injury. MAS = meconium aspiration syndrome
Fig. 3
Fig. 3
Distribution of serum creatinine in newborns with acute kidney injury.
Fig. 4
Fig. 4
Neutrophil gelatinase-associated lipocalin (NGAL) monitoring on the day of hospitalization and three days later.
Fig. 5
Fig. 5
Distribution of serum creatinine and urinary NGAL in newborns with acute kidney injury. Cr = creatinine; NGAL = neutrophil gelatinase-associated lipocalin
Fig. 6
Fig. 6
Values of urinary NGAL in newborns with AKI and lethal outcome compared to newborns without lethal outcome. NGAL = neutrophil gelatinase-associated lipocalin; AKI = acute kidney injury
See this image and copyright information in PMC

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