Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;14(4):683-691.
doi: 10.1055/s-0040-1713073. Epub 2020 Jul 29.

Mineral Trioxide Aggregate Applications in Endodontics: A Review

Gabriele Cervino  1 , Luigi Laino  2   1 , Cesare D'Amico  1 , Diana Russo  2 , Ludovica Nucci  2 , Giulia Amoroso  1 , Francesca Gorassini  1 , Michele Tepedino  3 , Antonella Terranova  1 , Dario Gambino  1 , Roberta Mastroieni  1 , Melek Didem Tözüm  4 , Luca Fiorillo  1
Affiliations

Mineral Trioxide Aggregate Applications in Endodontics: A Review

Gabriele Cervino et al. Eur J Dent. 2020 Oct.

Abstract

A current topic in dentistry concerns the biocompatibility of the materials, and in particular, conservative dentistry and endodontics ones. The mineral trioxide aggregate (MTA) is a dental material with biocompatibility properties to oral and dental tissues. MTA was developed for dental root repair in endodontic treatment and it is formulated from commercial Portland cement, combined with bismuth oxide powder for radiopacity. MTA is used for creating apical plugs during apexification, repairing root perforations during root canal therapy, treating internal root resorption, and pulp capping. The objective of this article is to investigate MTA features from a clinical point of view, even compared with other biomaterials. All the clinical data regarding this dental material will be evaluated in this review article. Data obtained from the analysis of the past 10 years' literature highlighted 19 articles in which the MTA clinical aspects could be recorded. The results obtained in this article are an important step to demonstrate the safety and predictability of oral rehabilitations with these biomaterials and to promote a line to improve their properties in the future.

PubMed Disclaimer

Conflict of interest statement

Conceptualization, methodology, validation, formal analysis, investigation, resources, data curation, original draft preparation, and review and editing of the manuscript were done by G.C., M.D.T., and L.F.; visualization was performed by D.R., L.N., and C.D.A.; data were curated by G.A., M.T., F.G., and A.T.; L.L. supervised the entire work and L.F. performed project administration.None declared.

Figures

Fig. 1
Fig. 1
Preferred reporting items for systematic reviews and meta-analyses flow chart.
Fig. 2
Fig. 2
Success rate frequency polygon chart of MTA (blue) versus other biomaterials. MTA, mineral trioxide aggregate.
Fig. 3
Fig. 3
SEM microleakage between MTA and bonding agents. The MTA use could, in some cases, make the definitive reconstruction complex due to the physical–chemical properties of itself and difficulty of use with hydrophobic substances. MTA, mineral trioxide aggregate; SEM, scanning electron microscope.
See this image and copyright information in PMC

References

    1. Tu M G, Sun K T, Wang T H et al. Effects of mineral trioxide aggregate and bioceramics on macrophage differentiation and polarization in vitro. J Formos Med Assoc. 2019;118(10):1458–1465. - PubMed
    1. Serin Kalay T. Effects of intracoronal bleaching agents on the surface properties of mineral trioxide aggregate. Odontology. 2019;107(04):465–472. - PubMed
    1. Lopes M B, Soares V CG, Fagundes F HR et al. Analysis of molecular changes induced by mineral trioxide aggregate on sPLA2. Braz Dent J. 2019;30(05):453–458. - PubMed
    1. Liu Y, Liu X M, Bi J et al. Cell migration and osteo/odontogenesis stimulation of iRoot FS as a potential apical barrier material in apexification. Int Endod J. 2020;53(04):467–477. - PubMed
    1. Lin YT, Lin YJ. Success rates of mineral trioxide aggregate, ferric sulfate, and sodium hypochlorite pulpotomies: a prospective 24-month study. J Formos Med Assoc 2019 - PubMed