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. 2020 Jul 29;11(1):3786.
doi: 10.1038/s41467-020-17580-z.

Advances in asymmetric organocatalysis over the last 10 years

Shao-Hua Xiang  1   2 , Bin Tan  3
Affiliations

Advances in asymmetric organocatalysis over the last 10 years

Shao-Hua Xiang et al. Nat Commun. .

Abstract

Beyond esoteric interest, organocatalysis has now become one major pillar of asymmetric catalysis. Here, we discuss how new activation modes are conquering challenging stereoselective transformations and the recent integration of organocatalysis with emerging photo- and electrocatalysis, as well as artificial intelligence.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Fig. 1
Fig. 1. Development of new catalytic strategies.
a Combination of organocatalysis with photocatalysis. b Carbonyl catalysis and organotextile catalysis. c Lewis acid enhancement by H-bond donor catalysis.
Fig. 2
Fig. 2. Important target-oriented developments.
a Chiral ion pair enabled quaternary carbon stereocenters construction in enantioconvergent manner. b Application in inactive alkene and arene activation.
See this image and copyright information in PMC

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