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Review
. 2020 Sep:81:1-8.
doi: 10.1016/j.ijsu.2020.07.032. Epub 2020 Jul 26.

A comparative overview of COVID-19, MERS and SARS: Review article

Jie Liu  1 , Wanli Xie  1 , Yanting Wang  1 , Yue Xiong  1 , Shiqiang Chen  1 , Jingjing Han  1 , Qingping Wu  2
Affiliations
Review

A comparative overview of COVID-19, MERS and SARS: Review article

Jie Liu et al. Int J Surg. 2020 Sep.

Abstract

Following the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), a third, highly pathogenic coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appearing at end of 2019 led to a pandemic, increased panic and attracted global attention. This review analyzes the epidemiology, etiology, clinical characteristics, treatment and sequelae of the severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS) and the 2019 novel coronavirus disease (COVID-19) to help provide direction for further studies that can help understand COVID-19.

Keywords: COVID-19; Epidemiology; MERS; SARS; SARS-CoV-2; Treatment.

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Conflict of interest statement

None.

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References

    1. Chan J.F.W., Li K.S.M., To K.K.W., Cheng V.C.C., Chen H., Yuen K.-Y. Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? J. Infect. 2012;65(6):477–489. - PMC - PubMed
    1. Gallagher T.M., Buchmeier M.J. Coronavirus spike proteins in viral entry and pathogenesis. Virology. 2001;279(2):371–374. - PMC - PubMed
    1. Kin N., Miszczak F., Lin W., Gouilh M.A., Vabret A. Genomic analysis of 15 human coronaviruses OC43 (HCoV-OC43s) circulating in France from 2001 to 2013 reveals a high intra-specific diversity with new recombinant genotypes. Viruses. 2015;7(5):2358–2377. - PMC - PubMed
    1. Ge X.-Y., Li J.-L., Yang X.-L., Chmura A.A., Zhu G., Epstein J.H., et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013;503(7477):535–538. - PMC - PubMed
    1. Lau S.K.P., Feng Y., Chen H., Luk H.K.H., Yang W.-H., Li K.S.M., et al. Severe acute respiratory syndrome (SARS) coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination. J. Virol. 2015;89(20):10532–10547. - PMC - PubMed

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