Reward Processing in Children With Disruptive Behavior Disorders and Callous-Unemotional Traits in the ABCD Study

Abstract

Objective: Disrupted reward processing is implicated in the etiology of disruptive behavior disorders (DBDs) and callous-unemotional traits. However, neuroimaging investigations of reward processing underlying these phenotypes remain sparse. The authors examined neural sensitivity in response to reward anticipation and receipt among youths with DBDs, with and without callous-unemotional traits.

Methods: Data were obtained from the Adolescent Brain and Cognitive Development Study (mean age=9.51 years [SD=0.50]; 49% female). Reward-related activation during the monetary incentive delay task was examined across 16 brain regions, including the amygdala, anterior cingulate cortex (ACC), nucleus accumbens (NAcc), and orbitofrontal cortex (OFC). Latent variable modeling was used to examine network-level coactivation. The following diagnostic groups were compared: typically developing youths (N=693) and youths with DBDs (N=995), subdivided into those with callous-unemotional traits (DBD+CU, N=198) and without callous-unemotional traits (DBD only, N=276).

Results: During reward anticipation, youths in the overall DBD group (with and without callous-unemotional traits) showed decreased dorsal ACC activation compared with typically developing youths. The DBD-only group exhibited reduced ventral and dorsal striatal activity compared with the DBD+CU and typically developing groups. During reward receipt, youths with DBDs showed increased cortical (e.g., OFC) and subcortical (e.g., NAcc) regional activation compared with typically developing youths. The DBD+CU group demonstrated greater activation in several regions compared with those in the typically developing (e.g., amygdala) and DBD-only (e.g., dorsal ACC) groups. At the network level, the DBD-only group showed reduced anticipatory reward activation compared with the typically developing and DBD+CU groups, whereas youths in the DBD+CU group showed increased activation during reward receipt compared with those in the typically developing group.

Conclusions: These findings advance our understanding of unique neuroetiologic pathways to DBDs and callous-unemotional traits.

Keywords: Callous-Unemotional; Disruptive Behavior Disorders; Pediatric; Reward Processing; fMRI.

Figure 1.

Study Regions of Interest

Figure 2.. Second-Order Latent Reward Network Factor

Notes. Amy = Amygdala; ACC (d) = dorsal Anterior Cingulate Cortex; ACC (p) = perigenual Anterior Cingulate Cortex; Cau = Caudate; Cun = Cuneus; Ins = Insula; Mdb = Midbrain; NAc = Nucleus Accumbens; Occ = Occipital Cortex; OFC = Orbitofrontal Cortex; PCC = Posterior Cingulate Cortex; PCG = Precentral Gyrus; Put = Putamen; SFG = Superior Frontal Gyrus; Thl = Thalamus; vmP = Ventromedial Prefrontal Cortex