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. 2020 Jul 30;20(1):359.
doi: 10.1186/s12887-020-02254-y.

The correlation between vitamin a status and refractory Mycoplasma Pneumoniae pneumonia (RMPP) incidence in children

Yuanyuan Li  1   2 , Ziyao Guo  1   2 , Guangli Zhang  3 , Xiaoyin Tian  3 , Qinyuan Li  1   2 , Dapeng Chen  4 , Zhengxiu Luo  5
Affiliations

The correlation between vitamin a status and refractory Mycoplasma Pneumoniae pneumonia (RMPP) incidence in children

Yuanyuan Li et al. BMC Pediatr. .

Abstract

Background: Vitamin A plays a pivotal role in respiratory infection, accurate estimation of vitamin A status was recommended in planning and implementing interventions. As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP). Mycoplasma pneumoniae is an important cause of respiratory infection in children, the association between vitamin A concentrations and refractory Mycoplasma pneumoniae pneumonia (RMPP) remains unclear.

Methods: 181 MPP patients were enrolled in this retrospective study, adjusted vitamin A concentrations and other parameters were compared between RMPP and general-MPP (GMPP) patients. Multivariate logistic regression test was performed to evaluate the association between vitamin A levels and RMPP incidence, linear correlation tests were applied to evaluate correlation between vitamin A concentrations and fever duration, length of stay (LOS).

Results: Vitamin A concentrations in RMPP group were significantly lower than those in GMPP patients (P < 0.05), vitamin A (OR = 0.795, 95% C. I 0.669-0.946) and CRP (OR = 1.050, 95% C. I 1.014-1.087) were independently associated with RMPP incidence. Linear correlation tests found vitamin A concentrations were negatively correlated with fever duration and LOS (P < 0.001).

Conclusions: Serum vitamin A concentrations were independently associated with RMPP incidence, which may correlate with reduced incidence of RMPP.

Keywords: Mycoplasma Pneumoniae pneumonia (MPP); Retinol-binding protein (RBP); Vitamin a.

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Conflict of interest statement

The authors declare no financial and non-financial competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the participants. As shown, a total of 291 cases met the inclusion criteria, after exclusion, 181 MPP patients were enrolled according to the inclusion and exclusion criteria, and then divided into RMPP group (n = 29) and GMPP group (n = 152). The vitamin A concentrations and other characteristics of each group were then determined
Fig. 2
Fig. 2
Correlation between serum vitamin A levels and clinical finding in MPP children. a Correlation between serum adjusted-vitamin A concentrations and fever duration in MPP children (r = − 0.378, P < 0.001). b Correlation between serum adjusted-vitamin A concentrations and LOS in MPP children (r = − 0.384, P < 0.001)
Fig. 3
Fig. 3
Correlation between serum adjusted-vitamin A levels and IL-6 concentrations in BALF in MPP children (r = − 0.321, P = 0.032)
See this image and copyright information in PMC

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