Comparative Study
Timolol. Hypotensive effect, used alone and in combination for treatment of increased intraocular pressure
- PMID: 32733
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Comparative Study
Timolol. Hypotensive effect, used alone and in combination for treatment of increased intraocular pressure
Acta Ophthalmol (Copenh).
1978.
Abstract
In 43 persons with increased intraocular pressure (IOP) Timolol maleate eye drops (0.25% and 0.5%) were used as a single and combined treatment. A significant decrease in IOP was noticed in 34 persons (P less than 0.001) initially. No diminished effect of treatment was apparent after 9 weeks in 34 subjects or after 15 weeks in 23 subjects with Timolol alone. In nine persons with high IOP, Timolol had a significant (P less than 0.001) but insufficient lowering effect. Epinephrine (1%) and acetazolamide appeared to have an additive effect in these cases. No serious local or systemic adverse effects were discovered.
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