Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jul 6:10:1071.
doi: 10.3389/fonc.2020.01071. eCollection 2020.

Commentary: Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Muhammad Abbas Abid  1 , Muhammad Bilal Abid  2
Affiliations
Comment

Commentary: Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Muhammad Abbas Abid et al. Front Oncol. .
No abstract available

Keywords: dietary interventions; gut microbiome; methionine restriction; precision oncology; tumor metabolism.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The role of methionine restriction in impeding tumor growth and its potential to improve outcomes in conjunction with gut microbiome manipulation: Resident gut taxa in the intestinal lumen produce metabolites (top panel) that direct T-cell differentiation and improve responses to immunotherapy (bottom left). Differential tumor growth in methionine enriched and depleted tumor microenvironments (bottom right).
See this image and copyright information in PMC

Comment on

References

    1. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Miyake K, et al. . Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. Oncotarget. (2018) 9:11119–25. 10.18632/oncotarget.24264 - DOI - PMC - PubMed
    1. Yano S, Li S, Han Q, Tan Y, Bouvet M, Fujiwara T, et al. . Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. Oncotarget. (2014) 5:8729–36. 10.18632/oncotarget.2369 - DOI - PMC - PubMed
    1. Goseki N, Yamazaki S, Shimojyu K, Kando F, Maruyama M, Endo M, et al. . Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial. Jpn J Cancer Res. (1995) 86:484–9. 10.1111/j.1349-7006.1995.tb03082.x - DOI - PMC - PubMed
    1. Durando X, Farges MC, Buc E, Abrial C, Petorin-Lesens C, Gillet B, et al. . Dietary methionine restriction with FOLFOX regimen as first line therapy of metastatic colorectal cancer: a feasibility study. Oncology. (2010) 78:205–9. 10.1159/000313700 - DOI - PubMed
    1. Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, et al. . Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature. (2019). 572:397–401. 10.1038/s41586-019-1437-3 - DOI - PMC - PubMed

LinkOut - more resources