Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;51(3):973-993.
doi: 10.1007/s10803-020-04618-w.

The Emergence of Autism Symptoms Prior to 18 Months of Age: A Systematic Literature Review

Affiliations

The Emergence of Autism Symptoms Prior to 18 Months of Age: A Systematic Literature Review

Amy Tanner et al. J Autism Dev Disord. 2021 Mar.

Abstract

Pre-diagnostic intervention for autism spectrum disorder (ASD) allows symptoms to be addressed as they emerge, often between six to 18 months, rather than after the full onset of the disorder. A systematic literature review, spanning the previous six years was conducted in order to provide an updated review looking at the earliest behavior symptoms of ASD. All included studies used a prospective experimental design, reported on symptoms that emerged before 18-months of age, exclusively in children who would later receive a diagnosis, and were assessed for quality. This review is the first to address this research question through the use of a systematic research design and extends the literature by following up on recommendations for future research from previous findings.

Keywords: Autism spectrum disorders; Early behavioral symptoms; Early screening; Systematic literature review.

PubMed Disclaimer

Conflict of interest statement

Author A and Author B declare that they have no conflict of interest to disclose regarding the present study.

Figures

Fig. 1
Fig. 1
Flow-chart illustrating inclusion process

References

    1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). 10.1176/appi.books.9780890425596
    1. Bedford R, Elsabbagh M, Gliga T, Pickles A, Senju A, Charman T, Johnson MH. Precursors to social and communication difficulties in infants at-risk for autism: Gaze following and attentional engagement. Journal of Autism and Developmental Disorders. 2012;42(10):2208–2218. doi: 10.1007/s10803-012-1450-y. - DOI - PubMed
    1. Bedford R, Jones EJ, Johnson MH, Pickles A, Charman T, Gliga T. Sex differences in the association between infant markers and later autistic traits. Molecular Autism. 2016 doi: 10.1186/s13229-016-0081-0. - DOI - PMC - PubMed
    1. Ben-Itzchak E, Zachor DA. The effects of intellectual functioning and autism severity on outcome of early behavioral intervention for children with autism. Research in Developmental Disabilities. 2007;28(3):287–303. doi: 10.1016/j.ridd.2006.03.002. - DOI - PubMed
    1. Ben-Sasson A, Hen L, Fluss R, Cermak S, Engel-Yeger B, Gal E. A meta-analysis of sensory modulation symptoms in individuals with Autism Spectrum Disorders. Journal of Developmental Disorders. 2009;39(1):1–11. doi: 10.1007/s10803-008-0593-3. - DOI - PubMed

Publication types