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. 2020 Aug 21;18(31):6108-6114.
doi: 10.1039/d0ob00485e. Epub 2020 Jul 31.

The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source

Bifu Liu  1 , Min Liu, Qiang Li, Yuanhua Li, Kejun Feng, Yongbo Zhou
Affiliations

The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source

Bifu Liu et al. Org Biomol Chem. .

Abstract

The ligand-free palladium-catalyzed C3-cyanation of indoles via direct C-H functionalization was achieved. This protocol, utilizing CH3CN as a green and readily available cyanide source, produced the desired products in moderate to good yields through transition-metal-catalyzed C-CN bond cleavage.

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