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Review
. 2021 Feb 18;114(1):3-10.
doi: 10.1093/qjmed/hcaa234.

Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic

M Verdoia  1 , G De Luca  2
Affiliations
Review

Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic

M Verdoia et al. QJM. .

Abstract

Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide and displaying a broad spectrum of implications on cardiovascular and inflammatory disorders. Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-CoV-2 infection. We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic.

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Figures

Figure 1.
Figure 1.
Worldwide distribution of vitamin D deficiency in healthy population (A, upper graph, 9) and of COVID-19 pandemic (B, lower graph).
Figure 2.
Figure 2.
Pathways of vitamin D metabolism and effectiveness.
Figure 3.
Figure 3.
Impact of vitamin D supplementation on the risk of acute respiratory infections (meta-analysis data from Martineau et al., 57) (suppl = supplementation).
See this image and copyright information in PMC

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