Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep:36:101655.
doi: 10.1016/j.redox.2020.101655. Epub 2020 Jul 25.

Nox2 activation in Covid-19

Francesco Violi  1 , Alessandra Oliva  2 , Roberto Cangemi  3 , Giancarlo Ceccarelli  2 , Pasquale Pignatelli  4 , Roberto Carnevale  5 , Vittoria Cammisotto  4 , Miriam Lichtner  2 , Francesco Alessandri  6 , Massimiliano De Angelis  2 , Maria Claudia Miele  2 , Gabriella D'Ettorre  2 , Franco Ruberto  6 , Mario Venditti  4 , Francesco Pugliese  4 , Claudio Maria Mastroianni  2
Affiliations

Nox2 activation in Covid-19

Francesco Violi et al. Redox Biol. 2020 Sep.

Abstract

Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.

Keywords: Covid-19; NADPH oxidase; Nox-2; Thrombosis.

PubMed Disclaimer

Conflict of interest statement

The short communication you find enclosed is submitted to the journal for publication.

The authors involved in this study declared that they do not possess any conflict of interest concerning the study and the issue evaluated in it.

read and approved the last version of the manuscript, that has not been submitted for publication elsewhere.RM118164366B89BD

Figures

Fig. 1
Fig. 1
Serum sNox2-dp in Covid-19 patients and controls (panel A), in Covid-19 patients admitted or not in intensive care unit (ICU) (panel B) and in Covid-19 patients who experienced or not thrombotic events (panel C). * Mann-Whitney U test.
See this image and copyright information in PMC

References

    1. Violi F., Ceccarelli G., Cangemi R., Alessandri F., Gabriella d’Ettorre G., Oliva A., Pastori D., Loffredo L., Pignatelli P., Ruberto F., Venditti M., Pugliese F., Hypoalbuminemia Mastroianni CM. Coagulopathy and vascular disease in covid-19. Circ. Res. 2020;127:400–401. - PubMed
    1. Violi F., Loffredo L., Carnevale R., Pignatelli P., Pastori D. Atherothrombosis and oxidative stress: mechanisms and management in elderly. Antioxidants Redox Signal. 2017;27:1083–1124. - PubMed
    1. Sirker A., Zhang M., Shah A.M. NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. Basic Res. Cardiol. 2011;106:735–747. - PMC - PubMed
    1. Violi F., Carnevale R., Loffredo L., Pignatelli P., Gallin J.I. NADPH oxidase-2 and atherothrombosis: insight from chronic granulomatous disease. Arterioscler. Thromb. Vasc. Biol. 2017;37:218–225. - PubMed
    1. Sonkar V.K., Kumar R., Jensen M., Wagner B.A., Sharathkumar A.A., Miller F.J., Jr., Fasano M., Lentz S.R., Buettner G.R., Dayal S. Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice. Blood Adv. 2019;3:1272–1284. - PMC - PubMed

Publication types

MeSH terms