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Review
. 2021 Feb;77(2):160-165.
doi: 10.1016/j.jjcc.2020.07.009. Epub 2020 Jul 30.

Iron and cardiovascular diseases

Yoshiro Naito  1 , Tohru Masuyama  2 , Masaharu Ishihara  3
Affiliations
Free article
Review

Iron and cardiovascular diseases

Yoshiro Naito et al. J Cardiol. 2021 Feb.
Free article

Abstract

Iron is a necessary element for life; however, excess iron leads to oxidative stress by the Fenton reaction. Iron deficiency is prevalent in patients with heart failure, while iron overload is associated in the pathogenesis of atherosclerosis. These findings suggest the "iron paradox" in cardiovascular diseases. Iron metabolism in cardiovascular diseases is complex, and the mechanisms regulating systemic and cellular iron metabolism in cardiovascular diseases remain completely unknown. In this review, we focus on the role of iron in cardiovascular diseases.

Keywords: Atherosclerosis; Heart failure; Iron; Transferrin receptor 1.

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