A mouse model of asthma-chronic obstructive pulmonary disease overlap induced by intratracheal papain

Kensuke Fukuda¹, Hirotaka Matsuzaki^{1

2}, Yu Mikami^{1

3}, Kosuke Makita^{1

4}, Kazuko Miyakawa¹, Naoya Miyashita¹, Keisuke Hosoki¹, Takashi Ishii^{1

5}, Satoshi Noguchi¹, Hirokazu Urushiyama¹, Masafumi Horie⁶, Akihisa Mitani^{1

5}, Yasuhiro Yamauchi⁷, Eri Shimura⁸, Susumu Nakae^{9

10}, Akira Saito^{1

5}, Takahide Nagase¹, Yoshihisa Hiraishi¹

Affiliations

¹ Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Centre for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan.
³ Marsico Lung Institute/UNC Cystic Fibrosis Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
⁴ Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
⁵ Division for Health Service Promotion, The University of Tokyo, Tokyo, Japan.
⁶ Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
⁷ Health Care Centre, Tokyo University of Foreign Studies, Tokyo, Japan.
⁸ Department of Chemistry, Juntendo University School of Medicine, Chiba, Japan.
⁹ The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
¹⁰ Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.

Kensuke Fukuda et al. Allergy. 2021 Jan.

. 2021 Jan;76(1):390-394.

doi: 10.1111/all.14528. Epub 2020 Aug 19.

¹ Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Centre for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan.
³ Marsico Lung Institute/UNC Cystic Fibrosis Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
⁴ Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
⁵ Division for Health Service Promotion, The University of Tokyo, Tokyo, Japan.
⁶ Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
⁷ Health Care Centre, Tokyo University of Foreign Studies, Tokyo, Japan.
⁸ Department of Chemistry, Juntendo University School of Medicine, Chiba, Japan.
⁹ The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
¹⁰ Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.

No abstract available

Keywords: COPD; animal models; asthma.

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