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Multicenter Study
. 2020 Jul;26(4):e161-e167.
doi: 10.1111/hae.14011. Epub 2020 Apr 27.

Depressive symptoms and adherence to prophylaxis in patients with haemophilia from Croatia and Slovenia

Martina Bago  1 , Ana Butkovic  2 , Irena Preloznik Zupan  3   4 , Barbara Faganel Kotnik  3   4 , Ivana Prga  1 , Vesna Bacic Vrca  5   6 , Silva Zupancic Salek  7   8
Affiliations
Multicenter Study

Depressive symptoms and adherence to prophylaxis in patients with haemophilia from Croatia and Slovenia

Martina Bago et al. Haemophilia. 2020 Jul.

Abstract

Introduction: Adherence to a prophylactic therapy is obligatory to prevent bleeding in patients with haemophilia. It has already been recognized that depression is associated with treatment adherence.

Aim: The aim of this study was to examine the prevalence of depressive symptoms in adults with haemophilia using an instrument designed or validated for diagnosing or screening for depression and to investigate the association of symptoms of depression with nonadherence to prophylactic therapy in patients from two East European countries.

Methods: Adult patients with severe or moderate haemophilia receiving prophylaxis were eligible for the study. Depressive symptoms were assessed with BDI-II, adherence with VERITAS-Pro, demographic and socioeconomic data were collected using a questionnaire, and clinical data were obtained from medical records.

Results: Final sample included 81 participants (median age was 45 years, range 18-73 years). There were 9 (11%) participants with scores on BDI-II above 14 points, the cut-off score for depressive symptomatology. In general, participants were adherent. However, there were 14 (17%) participants who had scores above 57 points, the cut-off score for nonadherence. There was an association between having depressive symptoms and being nonadherent, and depressive symptoms explained additional variance in adherence after controlling for sociodemographic, psychosocial and clinical characteristics.

Conclusion: Since there is an association between depressive symptoms and nonadherence, it would be beneficial for both patients and the public health system for screening for depressive symptoms to be included as a part of the treatment protocol.

Keywords: adherence; haemophilia; symptoms of depression.

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References

REFERENCES

    1. O'Hara J, Hughes D, Camp C, et al. The cost of severe haemophilia in Europe: the CHESS study. Orphanet J Rare Dis. 2017;12(1):106.
    1. Thornburg CD, Pipe SW. Adherence to prophylactic infusions of factor VIII or factor IX for haemophilia. Haemophilia. 2006;12(2):198-199.
    1. Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. Guidelines for the management of hemophilia. Haemophilia. 2013;19(1):e1-e47.
    1. Lindvall K, Von Mackensen S, Berntorp E. Quality of life in adult patients with haemophilia - a single centre experience from Sweden. Haemophilia. 2012;18(4):527-531.
    1. Llewellyn C, Miners A, Lee CA, Harrington C, Weinman J. The illness perceptions and treatment beliefs of individuals with severe haemophilia and their role in adherence to home treatment. Psychol Heal. 2003;18:185-200.

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