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. 2020;10(4):1643-1648.
doi: 10.3233/JPD-202116.

Hallucinations and Development of Dementia in Parkinson's Disease

Wojciech Gryc  1   2 , Kathryn A Roberts  1   2 , Cyrus P Zabetian  1   2 , Daniel Weintraub  3   4   5 , John Q Trojanowski  6   7 , Joseph F Quinn  8   9 , Amie L Hiller  8   9 , Kathryn A Chung  8   9 , Kathleen L Poston  10 , Laurice Yang  10 , Shu-Ching Hu  1   2 , Karen L Edwards  11 , Thomas J Montine  12 , Brenna A Cholerton  12
Affiliations

Hallucinations and Development of Dementia in Parkinson's Disease

Wojciech Gryc et al. J Parkinsons Dis. 2020.

Abstract

Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n = 696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p < 0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n = 444; p = 0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.

Keywords: Behavioral symptoms; Parkinson’s disease; cognition; dementia; hallucinations.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have no conflicts of interest relevant to this article to declare.

Figures

Figure 1.
Figure 1.
Kaplan-Meier survival estimates of time to dementia for initially non-demented participants with and without study partner reported hallucinations at baseline
See this image and copyright information in PMC

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