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Review
. 2020 Mar;24(1):3-14.
doi: 10.4235/agmr.20.0001. Epub 2020 Mar 24.

Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations

Zeev Meiner  1 , Emmeline Ayers  2 , Joe Verghese  2   3
Affiliations
Review

Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations

Zeev Meiner et al. Ann Geriatr Med Res. 2020 Mar.

Abstract

Changes in gait, especially decreased gait velocity, may be a harbinger of cognitive decline in aging. Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome combining slow gait and cognitive complaints, is a powerful clinical tool used to identify older adults at a high risk of developing dementia. The mean prevalence of MCR worldwide, including in a Korean cohort, was around 10%. The reported risk factors for incident MCR include older age, low education, cardiovascular disease, obesity, physical inactivity, and depression. In addition to dementia, MCR is also a risk factor for other age-related adverse conditions such as falls, disability, frailty, and mortality. The use of MCR has advantages over other pre-dementia syndromes in being much simpler to implement and requires fewer resources. Identification of mechanisms responsible for MCR may help in developing interventions to reduce the growing burden of dementia and disability worldwide.

Keywords: Cognitive impairment; Dementia; Gait; Motoric cognitive risk syndrome.

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Conflict of interest statement

CONFLICT OF INTEREST The researchers claim no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Brain areas involved in motoric cognitive risk syndrome (MCR) and related cognitive mechanisms responsible for gait control (white boxes, more atrophied regions as a function of MCR; black boxes, less atrophied regions as a function of MCR).
Fig. 2.
Fig. 2.
Potential biological mechanisms in mild cognitive impairment (MCI) and motoric cognitive risk syndrome (MCR).
See this image and copyright information in PMC

References

    1. United Nations Department of Economic and Social Affairs . World Population Prospects 2019: Highlights. New York, NY: United Nations; 2019.
    1. Alzheimer’s Disease International . World Alzheimer Report 2019: attitudes to dementia. London: Alzheimer’s Disease International; 2019.
    1. Verghese J, LeValley A, Hall CB, Katz MJ, Ambrose AF, Lipton RB. Epidemiology of gait disorders in community-residing older adults. J Am Geriatr Soc. 2006;54:255–61. - PMC - PubMed
    1. Montero-Odasso M, Verghese J, Beauchet O, Hausdorff JM. Gait and cognition: a complementary approach to understanding brain function and the risk of falling. J Am Geriatr Soc. 2012;60:2127–36. - PMC - PubMed
    1. Cohen JA, Verghese J. Gait and dementia. Handb Clin Neurol. 2019;167:419–27. - PubMed

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