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Case Reports
. 2018 Nov 24;2(1):19-22.
doi: 10.1002/iju5.12028. eCollection 2019 Jan.

Clear cell adenocarcinoma of the prostatic urethra: A case report

Rumiko Sugimura  1 , Takashi Kawahara  1   2 , Go Noguchi  3 , Daiji Takamoto  1 , Koji Izumi  1 , Yasuhide Miyoshi  1 , Takeshi Kishida  3 , Masahiro Yao  2 , Mikiko Tanabe  4 , Hiroji Uemura  1
Affiliations
Case Reports

Clear cell adenocarcinoma of the prostatic urethra: A case report

Rumiko Sugimura et al. IJU Case Rep. .

Abstract

Introduction: Clear cell adenocarcinoma of the prostatic urethra in men is an extremely rare disease, with only eight case reports published.

Case presentation: A 56-year-old man visited our hospital for gross hematuria. Urinary cytology detected class V, cystoscopy showed no abnormal findings, and contrast-enhanced computed tomography also showed no abnormal findings in his upper urinary tract except for a low-enhancement lesion on his left prostate lobe. Magnetic resonance imaging revealed a cystic lesion surrounding the prostate that was suspected of being urethral or prostate cancer, so transurethral resection was performed. A papillary tumor was detected at the prostatic urethra, and after resecting this tumor, a cavity showing multiple tumors was observed. The final pathological diagnosis was clear cell adenocarcinoma. Laparoscopic radical cystectomy and urethrectomy were thus performed. The pathological diagnosis was the same as at the primary tumor site.

Conclusion: We herein report a case of clear cell adenocarcinoma of the prostatic urethra.

Keywords: clear cell adenocarcinoma; prostatic urethra; urethra; urethral tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Non‐contrast and (b) contrast‐enhanced computed tomography. (c) Axial, (d) sagittal T2WI, (e) diffusion MRI findings.
Figure 2
Figure 2
Three‐dimensional image of the anatomic location.
Figure 3
Figure 3
(a,b) The tumor was located in the urethral diverticulum. HE findings: (c) the carcinomatous element consisted of CCA in the urethral diverticulum, (d) hobnail cells and (e) typical cytoplasm, and (f) immunohistochemical staining of PAX‐8.
See this image and copyright information in PMC

References

    1. Gakis G, Witjes JA, Comperat E et al EAU guidelines on primary urethral carcinoma. Eur. Urol. 2013; 64: 823–30. - PubMed
    1. Gandhi JS, Khurana A, Tewari A, Mehta A. Clear cell adenocarcinoma of the male urethral tract. Indian J. Pathol. Microbiol. 2012; 55: 245–7. - PubMed
    1. Aleksic I, Rais‐Bahrami S, Daugherty M, Agarwal PK, Vourganti S, Bratslavsky G. Primary urethral carcinoma: a surveillance, epidemiology, and end results data analysis identifying predictors of cancer‐specific survival. Urol. Ann. 2018; 10: 170–4. - PMC - PubMed
    1. Cantrell BB, Leifer G, DeKlerk DP, Eggleston JC. Papillary adenocarcinoma of the prostatic urethra with clear‐cell appearance. Cancer 1981; 48: 2661–7. - PubMed
    1. Oliva E, Young RH. Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. Mod. Pathol. 1996; 9: 513–20. - PubMed

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