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Comparative Study
. 2020 Sep 1;174(9):902-903.
doi: 10.1001/jamapediatrics.2020.3651.

Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)

Taylor Heald-Sargent  1 , William J Muller  1   2 , Xiaotian Zheng  1   2 , Jason Rippe  1 , Ami B Patel  1   2 , Larry K Kociolek  1   2
Affiliations
Comparative Study

Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)

Taylor Heald-Sargent et al. JAMA Pediatr. .

Abstract

This cohort study investigates age-related differences in nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus disease 2019 (COVID-19).

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Muller has received grants from Ansun BioPharma, Astellas Pharma, AstraZeneca, Abbott Laboratories, Janssen Pharmaceuticals, Karius, Merck, Melinta Therapeutics, Roche, Tetraphase Pharmaceuticals, and Seqirus. Dr Patel has received grants from Aqua Pharmaceuticals. Dr Kociolek has received grants from Merck. No other disclosures were reported.

Figures

Figure.
Figure.. Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcriptase–Polymerase Chain Reaction (RT-PCR) Amplification Cycle Threshold (CT) Values From Nasopharyngeal Swabs Collected From Patients With Coronavirus Disease 2019
Children younger than 5 years had significantly lower CT values compared with children aged 5 to 17 years (P = .02) and adults 18 years and older (P = .001). CT values were similar between children aged 5 to 17 years and adults 18 years and older (P = .34). Midlines indicate the median, boxes indicate interquartile ranges, whiskers indicate the upper and lower adjacent values (within 1.5-fold the interquartile range), and isolated data points indicate outliers.
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