Prospecting for molecular glues
- PMID: 32747810
- DOI: 10.1038/s41589-020-0620-z
Prospecting for molecular glues
Comment on
-
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3. Nature. 2020. PMID: 32494016 Free PMC article.
-
Rational discovery of molecular glue degraders via scalable chemical profiling.Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Nat Chem Biol. 2020. PMID: 32747809 Free PMC article.
References
-
- Burslem, G. M. & Crews, C. M. Chem. Rev. 117, 11269–11301 (2017). - DOI
-
- Hanan, E. J. et al. J. Med. Chem. https://doi.org/10.1021/acs.jmedchem.0c00093 (2020).
-
- Słabicki, M. et al. Nature https://doi.org/10.1038/s41586-020-2374-x (2020).
-
- Mayor-Ruiz, C. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0594-x (2020).
-
- Uehara, T. et al. Nat. Chem. Biol. 13, 675–680 (2017). - DOI
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
