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Review
. 2020 Oct;42(5):545-557.
doi: 10.1007/s00281-020-00806-z. Epub 2020 Aug 3.

The interplay between immunosenescence and age-related diseases

Florencia Barbé-Tuana  1 , Giselle Funchal  1 , Carine Raquel Richter Schmitz  2 , Rafael Moura Maurmann  1 , Moisés E Bauer  3   4
Affiliations
Review

The interplay between immunosenescence and age-related diseases

Florencia Barbé-Tuana et al. Semin Immunopathol. 2020 Oct.

Abstract

The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28-), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.

Keywords: Aging; Cell senescence; Cytokines; Immunosenescence; Inflammaging; T cells.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Multiple mechanisms of accelerated aging are similarly found in age-related diseases. Abbreviations: CMV, cytomegalovirus; SASP, senescence-associated secretory phenotype
See this image and copyright information in PMC

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