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Review
. 2021 Feb;14(2):e202000257.
doi: 10.1002/jbio.202000257. Epub 2020 Nov 3.

Strain and elasticity imaging in compression optical coherence elastography: The two-decade perspective and recent advances

Vladimir Y Zaitsev  1 , Alexander L Matveyev  1 , Lev A Matveev  1 , Alexander A Sovetsky  1 , Matt S Hepburn  2   3 , Alireza Mowla  2   3 , Brendan F Kennedy  2   3
Affiliations
Review

Strain and elasticity imaging in compression optical coherence elastography: The two-decade perspective and recent advances

Vladimir Y Zaitsev et al. J Biophotonics. 2021 Feb.

Abstract

Quantitative mapping of deformation and elasticity in optical coherence tomography has attracted much attention of researchers during the last two decades. However, despite intense effort it took ~15 years to demonstrate optical coherence elastography (OCE) as a practically useful technique. Similarly to medical ultrasound, where elastography was first realized using the quasi-static compression principle and later shear-wave-based systems were developed, in OCE these two approaches also developed in parallel. However, although the compression OCE (C-OCE) was proposed historically earlier in the seminal paper by J. Schmitt in 1998, breakthroughs in quantitative mapping of genuine local strains and the Young's modulus in C-OCE have been reported only recently and have not yet obtained sufficient attention in reviews. In this overview, we focus on underlying principles of C-OCE; discuss various practical challenges in its realization and present examples of biomedical applications of C-OCE. The figure demonstrates OCE-visualization of complex transient strains in a corneal sample heated by an infrared laser beam.

Keywords: OCT; compression elastography; elasticity mapping; optical coherence elastography; strain mapping; tissue biomechanics.

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References

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