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Review
. 2022;211(2):91-109.
doi: 10.1159/000510103. Epub 2020 Aug 4.

Clinical Impact of the Epithelial-Mesenchymal Transition in Lung Cancer as a Biomarker Assisting in Therapeutic Decisions

Julien Ancel  1   2 , Maxime Dewolf  2 , Gaëtan Deslée  1   2 , Béatrice Nawrocky-Raby  1 , Véronique Dalstein  1   3 , Christine Gilles  4 , Myriam Polette  1   3
Affiliations
Free article
Review

Clinical Impact of the Epithelial-Mesenchymal Transition in Lung Cancer as a Biomarker Assisting in Therapeutic Decisions

Julien Ancel et al. Cells Tissues Organs. 2022.
Free article

Abstract

Lung cancer is one of the most common solid cancers and represents the leading cause of cancer death worldwide. Over the last decade, research on the epithelial-mesenchymal transition (EMT) in lung cancer has gained increasing attention. Here, we review clinical and histological features of non-small-cell lung cancer associated with EMT. We then aimed to establish potential clinical implications of EMT in current therapeutic options, including surgery, radiation, targeted therapy against oncogenic drivers, and immunotherapy.

Keywords: Epithelial-mesenchymal transition; Non-small-cell lung cancer; Resistance; Therapy.

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