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. 2020 Jul 31;8(3):52.
doi: 10.3390/toxics8030052.

Ambient Exposure to Agricultural Pesticides during Pregnancy and Risk of Cerebral Palsy: A Population-Based Study in California

Zeyan Liew  1   2 , Ondine S von Ehrenstein  3   4 , Chenxiao Ling  4 , Yuying Yuan  4 , Qi Meng  4 , Xin Cui  5   6 , Andrew S Park  4 , Peter Uldall  7 , Jørn Olsen  8 , Myles Cockburn  9   10   11 , Beate Ritz  4   12
Affiliations

Ambient Exposure to Agricultural Pesticides during Pregnancy and Risk of Cerebral Palsy: A Population-Based Study in California

Zeyan Liew et al. Toxics. .

Abstract

Cerebral palsy (CP) is the most common neuro-motor disability in young children. Disruptions of maternal hormone function during pregnancy have been linked to CP risk. We investigated whether prenatal exposure to pesticide compounds with endocrine-disrupting action affect CP risk. We conducted a case-control study of 3905 CP cases and 39,377 controls born between 1998 and 2010 in California to mothers who lived in proximity (within 2 km) to any agricultural pesticide application recorded in the California Pesticide Use Reporting (PUR) system. We focused on 23 pesticides considered endocrine disruptors that are frequently used, and we found that exposure to any of the 23 pesticides in the first trimester was associated with elevated CP risks in female offspring (OR = 1.19; 95% CI: 1.05-1.35) but not males (OR = 0.99; 95% CI: 0.89-1.09) compared to the unexposed offspring. Positive associations were estimated for 15 pesticides suspected to affect the estrogen and 7 pesticides suspected to affect the thyroid hormone system. Our study suggests that first trimester exposure to pesticides that are suspected endocrine disruptors are associated with CP risk in female offspring. Pesticide exposures in early pregnancy may have sex-specific influences on the neuro-motor development of the fetus by interfering with endocrine systems.

Keywords: cerebral palsy; endocrine-disrupting chemical (EDC); movement disorders; neurodevelopment; pesticide.

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Conflict of interest statement

The authors declare no actual conflict of interest.

References

    1. Rosenbaum P., Paneth N., Leviton A., Goldstein M., Bax M., Damiano D., Dan B., Jacobsson B. A report: The definition and classification of cerebral palsy April 2006. Dev. Med. Child Neurol. Suppl. 2007;109:8–14. - PubMed
    1. Ravn S.H., Flachs E.M., Uldall P. Cerebral palsy in eastern Denmark: Declining birth prevalence but increasing numbers of unilateral cerebral palsy in birth year period 1986–1998. Eur. J. Paediatr. Neurol. 2010;14:214–218. doi: 10.1016/j.ejpn.2009.06.001. - DOI - PubMed
    1. Clark S.M., Ghulmiyyah L.M., Hankins G.D.V. Antenatal antecedents and the impact of obstetric care in the etiology of cerebral palsy. Clin. Obstet. Gynecol. 2008;51:775–786. doi: 10.1097/GRF.0b013e3181870994. - DOI - PubMed
    1. Schendel D.E., Schuchat A., Thorsen P. Public health issues related to infection in pregnancy and cerebral palsy. Ment. Retard. Dev. Disabil. Res. Rev. 2002;8:39–45. doi: 10.1002/mrdd.10011. - DOI - PubMed
    1. Surveillance of Cerebral Palsy in Europe (SCPE) Surveillance of Cerebral Palsy in Europe (SCPE). Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Dev. Med. Child Neurol. 2000;42:816–824. - PubMed

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